HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

Anna Calliari; Lillian M. Daughrity; Ellen A. Albagli; Paula Castellanos Otero; Mei Yue; Karen Jansen-West; Naeyma N. Islam; Thomas Caulfield; Bailey Rawlinson; Michael DeTure; Casey Cook; Neill R. Graff-Radford; Gregory S. Day; Bradley F. Boeve; David S. Knopman; Ronald C. Petersen; Keith A. Josephs; Björn Oskarsson; Aaron D. Gitler; Dennis W. Dickson; Tania F. Gendron; Mercedes Prudencio; Michael E. Ward; Yong Jie Zhang; Leonard Petrucelli

doi:10.1186/s13024-024-00718-8

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. DicksonTania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong Jie Zhang, Leonard Petrucelli

Research output: Contribution to journal › Letter › peer-review

Abstract

This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.

Original language	English (US)
Article number	29
Journal	Molecular neurodegeneration
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13024-024-00718-8
State	Published - Dec 2024

ASJC Scopus subject areas

Molecular Biology
Clinical Neurology
Cellular and Molecular Neuroscience

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Calliari, A., Daughrity, L. M., Albagli, E. A., Castellanos Otero, P., Yue, M., Jansen-West, K., Islam, N. N., Caulfield, T., Rawlinson, B., DeTure, M., Cook, C., Graff-Radford, N. R., Day, G. S., Boeve, B. F., Knopman, D. S., Petersen, R. C., Josephs, K. A., Oskarsson, B., Gitler, A. D., ... Petrucelli, L. (2024). HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases. Molecular neurodegeneration, 19(1), Article 29. https://doi.org/10.1186/s13024-024-00718-8

Calliari, A, Daughrity, LM, Albagli, EA, Castellanos Otero, P, Yue, M, Jansen-West, K, Islam, NN, Caulfield, T, Rawlinson, B, DeTure, M , Cook, C , Graff-Radford, NR, Day, GS, Boeve, BF , Knopman, DS, Petersen, RC, Josephs, KA , Oskarsson, B, Gitler, AD, Dickson, DW , Gendron, TF , Prudencio, M, Ward, ME, Zhang, YJ & Petrucelli, L 2024, 'HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases', Molecular neurodegeneration, vol. 19, no. 1, 29. https://doi.org/10.1186/s13024-024-00718-8

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title = "HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases",

abstract = "This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.",

author = "Anna Calliari and Daughrity, {Lillian M.} and Albagli, {Ellen A.} and {Castellanos Otero}, Paula and Mei Yue and Karen Jansen-West and Islam, {Naeyma N.} and Thomas Caulfield and Bailey Rawlinson and Michael DeTure and Casey Cook and Graff-Radford, {Neill R.} and Day, {Gregory S.} and Boeve, {Bradley F.} and Knopman, {David S.} and Petersen, {Ronald C.} and Josephs, {Keith A.} and Bj{\"o}rn Oskarsson and Gitler, {Aaron D.} and Dickson, {Dennis W.} and Gendron, {Tania F.} and Mercedes Prudencio and Ward, {Michael E.} and Zhang, {Yong Jie} and Leonard Petrucelli",

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month = dec,

doi = "10.1186/s13024-024-00718-8",

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AU - Calliari, Anna

AU - Daughrity, Lillian M.

AU - Albagli, Ellen A.

AU - Castellanos Otero, Paula

AU - Yue, Mei

AU - Jansen-West, Karen

AU - Islam, Naeyma N.

AU - Caulfield, Thomas

AU - Rawlinson, Bailey

AU - DeTure, Michael

AU - Cook, Casey

AU - Graff-Radford, Neill R.

AU - Day, Gregory S.

AU - Boeve, Bradley F.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Josephs, Keith A.

AU - Oskarsson, Björn

AU - Gitler, Aaron D.

AU - Dickson, Dennis W.

AU - Gendron, Tania F.

AU - Prudencio, Mercedes

AU - Ward, Michael E.

AU - Zhang, Yong Jie

AU - Petrucelli, Leonard

PY - 2024/12

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N2 - This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.

AB - This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.

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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

Abstract

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