Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers

Maria Victoria Botuyan, Georges Mer

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The Tudor domain is a methyl-lysine and methyl-arginine binding domain present in proteins involved in cellular functions as diverse as DNA transcription, RNA metabolism, gene silencing, the transmission of epigenetic posttranslational modifications, and the maintenance of genomic stability. In this chapter, we review the different forms-single Tudor, tandem Tudor, hybrid Tudor, extended Tudor-and substrate binding modes, including methylation-state specificity, of the Tudor domain. Our focus is on proteins for which three-dimensional structures of Tudor domains in complex with lysine- or arginine-methylated substrates are available. The functional significance of Tudor proteins in chromatin signaling and possible involvement in diseases are highlighted.

Original languageEnglish (US)
Title of host publicationChromatin Signaling and Diseases
PublisherElsevier Inc.
Number of pages17
ISBN (Electronic)9780128026090
ISBN (Print)9780128023891
StatePublished - Aug 24 2016


  • DNA damage response
  • DNA transcription
  • Epigenetics
  • Gene silencing
  • Methyl-arginine
  • Methyl-lysine
  • Non-coding RNA
  • Royal Family
  • Tudor domain

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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