Abstract
Background: The calcium-binding protein DREAM/KChIP3 binds DNA and other proteins to regulate neuronal function. Results: DREAM/KChIP3 binds the EF-hand protein, calmodulin, in the presence but not in the absence of calcium. Calciumbound DREAM/KChIP3 enhances calmodulin-dependent calcineurin activity. Conclusion: DREAM/KChIP3 binds and regulates calmodulin activity. Significance: DREAM/KChIP3 heterodimerizes with the EF-hand protein, calmodulin, and regulates calmodulin activation of calcineurin.
Original language | English (US) |
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Pages (from-to) | 39439-39448 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 47 |
DOIs | |
State | Published - Nov 16 2012 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology