Management of rhinosinusitis during pregnancy: Systematic review and expert panel recommendations

Devyani Lal, Ameya A. Jategaonkar, Larry Borish, Linda R. Chambliss, Sharon H. Gnagi, Peter H. Hwang, Matthew A. Rank, James A. Stankiewicz, Valerie J. Lund

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Background: Management of rhinosinusitis during pregnancy requires special considerations. Objectives: 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations. Methods: The systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea. Results: Eighty-eight manuscripts underwent full review after screening 3052 abstracts. No relevant level 1, 2, or 3 studies were found. Expert panel recommendations for rhinosinusitis management during pregnancy included continuing nasal corticosteroid sprays for CRS maintenance, using pregnancy-safe antibiotics for acute rhinosinusitis and CRS exacerbations, and discontinuing aspirin desensitization for aspirin exacerbated respiratory disease. The manuscript presents detailed recommendations. Conclusions: The lack of evidence pertinent to managing rhinosinusitis during pregnancy warrants future trials. Expert recommendations constitute the current best available evidence.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
Issue number2
StatePublished - 2016


  • Drug therapy
  • Guideline
  • Paranasal sinus diseases
  • Pregnancy
  • Sinusitis

ASJC Scopus subject areas

  • Otorhinolaryngology


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