Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM

Jacob J. Orme; Georges Mer; Haojie Huang

doi:10.1016/j.molcel.2023.02.003

Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM

Jacob J. Orme, Georges Mer, Haojie Huang

Biochemistry and Molecular Biology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.¹ show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.

Original language	English (US)
Pages (from-to)	655-656
Number of pages	2
Journal	Molecular Cell
Volume	83
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2023.02.003
State	Published - Mar 2 2023

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2023.02.003

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title = "Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM",

abstract = "Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.1 show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.",

author = "Orme, {Jacob J.} and Georges Mer and Haojie Huang",

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year = "2023",

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AU - Orme, Jacob J.

AU - Mer, Georges

AU - Huang, Haojie

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Y1 - 2023/3/2

N2 - Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.1 show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.

AB - Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.1 show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.

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Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM

Abstract

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