TY - JOUR
T1 - Growth factor receptor signalling
T2 - Location, location, location
AU - Leof, Edward B.
N1 - Funding Information:
I thank Drs Richard Pagano and Mark McNiven and members of my laboratory for helpful discussions. These studies were supported by grants GM54200 and GM55816 from the National Institutes of Health.
PY - 2000/8/1
Y1 - 2000/8/1
N2 - Ligand binding to plasma membrane receptors initiates a series of events culminating in a variety of changes in cellular phenotypes. Although numerous publications have documented the activation/inactivation of signalling molecules following receptor binding1,2, relatively few investigations have focused on the cellular compartment responsible for either initiating or selecting the particular pathway that mediates the response3. Specifically, does receptor signalling occur only at the plasma membrane; is signalling dependent upon the location of defined endosome populations; or are components of both plasma membrane and endosomal activity operative depending upon the particular signalling pathway or cell type? This review addresses aspects of these questions by discussing the evidence supporting or contrasting the interplay between the endocytic and signalling systems for a subset of tyrosine kinase, serine/threonine kinase and G-protein-coupled receptors. Copyright (C) 2000 Elsevier Science Ltd.
AB - Ligand binding to plasma membrane receptors initiates a series of events culminating in a variety of changes in cellular phenotypes. Although numerous publications have documented the activation/inactivation of signalling molecules following receptor binding1,2, relatively few investigations have focused on the cellular compartment responsible for either initiating or selecting the particular pathway that mediates the response3. Specifically, does receptor signalling occur only at the plasma membrane; is signalling dependent upon the location of defined endosome populations; or are components of both plasma membrane and endosomal activity operative depending upon the particular signalling pathway or cell type? This review addresses aspects of these questions by discussing the evidence supporting or contrasting the interplay between the endocytic and signalling systems for a subset of tyrosine kinase, serine/threonine kinase and G-protein-coupled receptors. Copyright (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0962-8924(00)01795-5
DO - 10.1016/S0962-8924(00)01795-5
M3 - Review article
C2 - 10884687
AN - SCOPUS:0034255905
SN - 0962-8924
VL - 10
SP - 343
EP - 348
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -