Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

Annina M. DeLeo, Tsuneya Ikezu

Research output: Contribution to journalReview articlepeer-review


Extracellular vesicles (EVs) are physiological vesicles secreted from most eukaryotes and contain cargos of their cell of origin. EVs, and particularly a subset of EV known as exosomes, are emerging as key mediators of cell to cell communication and waste management for cells both during normal organismal function and in disease. In this review, we investigate the rapidly growing field of exosome biology, their biogenesis, cargo loading, and uptake by other cells. We particularly consider the role of exosomes in Alzheimer’s disease, both as a pathogenic agent and as a disease biomarker. We also explore the emerging role of exosomes in chronic traumatic encephalopathy. Finally, we highlight open questions in these fields and the possible use of exosomes as therapeutic targets and agents.

Original languageEnglish (US)
Pages (from-to)292-308
Number of pages17
JournalJournal of Neuroimmune Pharmacology
Issue number3
StatePublished - Sep 1 2018


  • Alzheimer’s disease
  • Amyloid-β peptide
  • Chronic traumatic encephalopathy
  • Exosomes
  • Extracellular vesicles
  • Microglia
  • Microtubule-associated protein tau
  • Microvesicles
  • Tauopathy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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