Bile acid regulation of hepatic physiology IV. Bile acids and death receptors

Hajime Higuchi, Gregory J. Gores

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor oligomerization and activation. Bile acid modulation of death-receptor signaling is multifactorial and includes trafficking of Fas to the cell surface, enhancing TRAIL-R2/DR5 expression, and suppression of function of cFLIP, an antiapoptotic protein modulating death-receptor function. Because bile acid-associated death receptor-mediated apoptosis is a common mechanism for cholestatic hepatocyte injury, inhibition of death receptors and their cascades may prove useful in attenuating liver injury during cholestasis.

Original languageEnglish (US)
Pages (from-to)G734-G738
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number5 47-5
StatePublished - May 1 2003


  • Bid
  • Fas
  • Tumor necrosis factor-associated apoptosis-inducing ligand

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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