Projects per year
Personal profile
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Education/Academic qualification
Fellow - Department of Internal Medicine; Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
MD, University of North Dakota
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Collaborations and top research areas from the last five years
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Mayo Clinic Hepatobiliary SPORE
Mc Niven, M. M. A. (PI), Alberts, S. R. (CoPI), Wang, C. C. (CoPI), Gores, G. J. (CoPI), Leof, E. B. (CoPI), Roberts, L. R. (CoPI), Mandrekar, S. J. (CoPI), Smoot, R. (CoPI), Simon, S. M. (CoPI), Torbenson, M. (CoPI), Vile, R. G. (CoPI) & Yin, V. (CoPI)
9/10/18 → 8/31/25
Project: Research project
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Mayo Center for Cell Signaling in Gastroenterology
La Russo, N. F. (PI), Boardman, L. A. (CoPI), Ekker, S. C. (CoPI), Ekker, S. C. (CoPI), Farrugia, G. (CoPI), Faubion, W. A. (CoPI), Gores, G. J. (CoPI), Larusso, N. N. F. (CoPI), Mc Niven, M. A. (CoPI), Mc Niven, M. A. (CoPI), Shah, V. (CoPI), Ibrahim, S. S. (CoPI) & Ordog, T. (CoPI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/09 → 6/30/25
Project: Research project
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Cholestatic Liver Injury
Gores, G. J. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
4/1/20 → 3/31/24
Project: Research project
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Enrichment Program
Gores, G. J. (PI) & Gores, G. G. J. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/19 → 6/30/24
Project: Research project
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Project 2: Therapeutic Inhibition of Fibroblast Growth Factor and YAP Signaling in Cholangiocarcinoma: Preclinical Studies and Clinical Trial
Gores, G. J. (PI) & Gores, G. G. J. (PI)
9/1/18 → 8/31/23
Project: Research project
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Small intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies
Shah, A., Spannenburg, L., Thite, P., Morrison, M., Fairlie, T., Koloski, N., Kashyap, P. C., Pimentel, M., Rezaie, A., Gores, G. J., Jones, M. P. & Holtmann, G., Feb 2025, In: EClinicalMedicine. 80, 103024.Research output: Contribution to journal › Article › peer-review
Open Access -
Transposon-based oncogene integration in Abcb4(Mdr2)-/- mice recapitulates high susceptibility to cholangiocarcinoma in primary sclerosing cholangitis
Huang, P., Wei, G., Kirkpatrick, J. D., Lin, Y., Tan, L., Matta, H., Nasser, I., Huang, M., Chen, L., Petitjean, M., Skelton-Badlani, D., Gao, W., Vaid, K., Zhao, S., Lugovskoy, A., Alenzi, M., Chen, X., Gores, G. J. & Popov, Y. V., Jan 2025, In: Journal of hepatology. 82, 1, p. 84-96 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Alcohol-associated liver disease: The time to act is now
Malhi, H. & Gores, G. J., Dec 1 2024, In: Hepatology. 80, 6, p. 1305-1306 2 p.Research output: Contribution to journal › Editorial › peer-review
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A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis
Watkins, R., Gamo, A., Choi, S. H., Kumar, M., Buckarma, E. L., McCabe, C., Tomlinson, J., Pereya, D., Lupse, B., Geravandi, S., Werneburg, N. W., Wang, C., Starlinger, P., Zhu, S., Li, S., Yu, S., Surakattula, M., Baguley, T., Ardestani, A. & Maedler, K. & 10 others, , Mar 1 2024, In: PNAS Nexus. 3, 3Research output: Contribution to journal › Article › peer-review
Open Access -
Central Role for Cholangiocyte Pathobiology in Cholestatic Liver Diseases
Jalan-Sakrikar, N., Guicciardi, M. E., O'Hara, S. P., Azad, A., LaRusso, N. F., Gores, G. J. & Huebert, R. C., 2024, (Accepted/In press) In: Hepatology. 10.1097/HEP.0000000000001093.Research output: Contribution to journal › Article › peer-review