An ATM D-compartmentalization in DNA damage response

Anjali Prasad; Arun Kanakkanthara

doi:10.1016/j.tcb.2023.12.003

An ATM D-compartmentalization in DNA damage response

Anjali Prasad, Arun Kanakkanthara

Medical Oncology

Research output: Contribution to journal › Short survey › peer-review

Abstract

How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.

Original language	English (US)
Pages (from-to)	173-175
Number of pages	3
Journal	Trends in Cell Biology
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.tcb.2023.12.003
State	Published - Mar 2024

Keywords

ATM
D compartment
DNA damage response
DNA repair
chromatin compartmentalization
genome integrity

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2023.12.003

Cite this

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title = "An ATM D-compartmentalization in DNA damage response",

abstract = "How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.",

keywords = "ATM, D compartment, DNA damage response, DNA repair, chromatin compartmentalization, genome integrity",

author = "Anjali Prasad and Arun Kanakkanthara",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2024",

month = mar,

doi = "10.1016/j.tcb.2023.12.003",

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AU - Prasad, Anjali

AU - Kanakkanthara, Arun

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AB - How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.

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KW - D compartment

KW - DNA damage response

KW - DNA repair

KW - chromatin compartmentalization

KW - genome integrity

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DO - 10.1016/j.tcb.2023.12.003

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An ATM D-compartmentalization in DNA damage response

Abstract

Keywords

ASJC Scopus subject areas

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