A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

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76 Scopus citations


The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.

Original languageEnglish (US)
Pages (from-to)664-675
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number7
StatePublished - Jul 2009


  • Aggregation
  • Alpha-synuclein
  • DJ-1
  • Leucine-rich repeat kinase 2
  • Lewy bodies
  • Parkin
  • Parkinson's disease
  • Substantia nigra
  • Ubiquitin ligase
  • Ubiquitin proteasome system

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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