Abstract
The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.
Original language | English (US) |
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Pages (from-to) | 664-675 |
Number of pages | 12 |
Journal | Biochimica et Biophysica Acta - Molecular Basis of Disease |
Volume | 1792 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2009 |
Keywords
- Aggregation
- Alpha-synuclein
- DJ-1
- Leucine-rich repeat kinase 2
- Lewy bodies
- Parkin
- Parkinson's disease
- Substantia nigra
- Ubiquitin ligase
- Ubiquitin proteasome system
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology