Iftikhar Jan Kullo

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Iftikhar Jan Kullo, MD

1995 …2024

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  • 2024

    A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease

    Norland, K., Schaid, D. J. & Kullo, I. J., Feb 2024, In: European Journal of Human Genetics. 32, 2, p. 209-214 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels

    Bangash, H., Saadatagah, S., Naderian, M., Hamed, M. E., Alhalabi, L., Sherafati, A., Sutton, J., Elsekaily, O., Mir, A., Gundelach, J. H., Gibbons, D., Johnsen, P., Wood-Wentz, C. M., Smith, C. Y., Caraballo, P. J., Bailey, K. R. & Kullo, I. J., Dec 2024, In: npj Digital Medicine. 7, 1, 73.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size

    Agrawal, V., Manouchehri, A., Vaitinadin, N. S., Shi, M., Bagheri, M., Gupta, D. K., Kullo, I. J., Luo, Y., Mcnally, E. M., Puckelwartz, M. J., Ferguson, J. F., Wells, Q. S. & Mosley, J. D., Jan 1 2024, In: Circulation: Heart Failure. 17, 1, p. E010557

    Research output: Contribution to journal › Article › peer-review

  • Rare loss-of-function variants in matrisome genes are enriched in Ebstein's anomaly

    Zhou, Z., Tang, X., Chen, W., Chen, Q., Ye, B., Johar, A. S., Kullo, I. J. & Ding, K., Jan 11 2024, In: Human Genetics and Genomics Advances. 5, 1, 100258.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

    Lennon, N. J., Kottyan, L. C., Kachulis, C., Abul-Husn, N. S., Arias, J., Belbin, G., Below, J. E., Berndt, S. I., Chung, W. K., Cimino, J. J., Clayton, E. W., Connolly, J. J., Crosslin, D. R., Dikilitas, O., Velez Edwards, D. R., Feng, Q. P., Fisher, M., Freimuth, R. R., Ge, T., Glessner, J. T., & 60 othersGordon, A. S., Patterson, C., Hakonarson, H., Harden, M., Harr, M., Hirschhorn, J. N., Hoggart, C., Hsu, L., Irvin, M. R., Jarvik, G. P., Karlson, E. W., Khan, A., Khera, A., Kiryluk, K., Kullo, I., Larkin, K., Limdi, N., Linder, J. E., Loos, R. J. F., Luo, Y., Malolepsza, E., Manolio, T. A., Martin, L. J., McCarthy, L., McNally, E. M., Meigs, J. B., Mersha, T. B., Mosley, J. D., Musick, A., Namjou, B., Pai, N., Pesce, L. L., Peters, U., Peterson, J. F., Prows, C. A., Puckelwartz, M. J., Rehm, H. L., Roden, D. M., Rosenthal, E. A., Rowley, R., Sawicki, K. T., Schaid, D. J., Smit, R. A. J., Smith, J. L., Smoller, J. W., Thomas, M., Tiwari, H., Toledo, D. M., Vaitinadin, N. S., Veenstra, D., Walunas, T. L., Wang, Z., Wei, W. Q., Weng, C., Wiesner, G. L., Yin, X., Kenny, E. E., Berndt, S., Hirschhorn, J. & Loos, R., Feb 2024, In: Nature Medicine. 30, 2, p. 480-487 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2023

    Biomarkers and cardiovascular events in patients with stable coronary disease in the ISCHEMIA Trials

    ISCHEMIA Biorepository Research Group, Dec 2023, In: American heart journal. 266, p. 61-73 13 p.

    Research output: Contribution to journal › Article › peer-review

  • Characterizing variability of electronic health record-driven phenotype definitions

    Brandt, P. S., Kho, A., Luo, Y., Pacheco, J. A., Walunas, T. L., Hakonarson, H., Hripcsak, G., Liu, C., Shang, N., Weng, C., Walton, N., Carrell, D. S., Crane, P. K., Larson, E. B., Chute, C. G., Kullo, I. J., Carroll, R., Denny, J., Ramirez, A., Wei, W. Q., & 5 othersPathak, J., Wiley, L. K., Richesson, R., Starren, J. B. & Rasmussen, L. V., Mar 1 2023, In: Journal of the American Medical Informatics Association. 30, 3, p. 427-437 11 p.

    Research output: Contribution to journal › Article › peer-review

  • Clinician Perspectives on Clinical Decision Support for Familial Hypercholesterolemia

    Bangash, H., Elsekaily, O., Saadatagah, S., Sutton, J., Johnsen, P., Gundelach, J. H., Kamzabek, A., Freimuth, R., Caraballo, P. J. & Kullo, I. J., Jun 2023, In: Journal of Personalized Medicine. 13, 6, 929.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Daytime Versus Nighttime Ambulatory Blood Pressure Monitoring in Coarctation of Aorta

    Egbe, A. C., Miranda, W. R., Connolly, H. M., Kullo, I. J. & Borlaug, B. A., Aug 1 2023, In: Hypertension. 80, 8, p. E134-E136

    Research output: Contribution to journal › Article › peer-review

  • Deep generative models of LDLR protein structure to predict variant pathogenicity

    James, J. K., Norland, K., Johar, A. S. & Kullo, I. J., Dec 2023, In: Journal of Lipid Research. 64, 12, 100455.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network

    Pacheco, J. A., Rasmussen, L. V., Wiley, K., Person, T. N., Cronkite, D. J., Sohn, S., Murphy, S., Gundelach, J. H., Gainer, V., Castro, V. M., Liu, C., Mentch, F., Lingren, T., Sundaresan, A. S., Eickelberg, G., Willis, V., Furmanchuk, A., Patel, R., Carrell, D. S., Deng, Y., & 19 othersWalton, N., Satterfield, B. A., Kullo, I. J., Dikilitas, O., Smith, J. C., Peterson, J. F., Shang, N., Kiryluk, K., Ni, Y., Li, Y., Nadkarni, G. N., Rosenthal, E. A., Walunas, T. L., Williams, M. S., Karlson, E. W., Linder, J. E., Luo, Y., Weng, C. & Wei, W. Q., Dec 2023, In: Scientific reports. 13, 1, 1971.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets

    Singhal, P., Veturi, Y., Dudek, S. M., Lucas, A., Frase, A., van Steen, K., Schrodi, S. J., Fasel, D., Weng, C., Pendergrass, R., Schaid, D. J., Kullo, I. J., Dikilitas, O., Sleiman, P. M. A., Hakonarson, H., Moore, J. H., Williams, S. M., Ritchie, M. D. & Verma, S. S., Apr 6 2023, In: American journal of human genetics. 110, 4, p. 575-591 17 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Examining the Impact of Polygenic Risk Information in Primary Care

    Pacyna, J. E., Ennis, J. S., Kullo, I. J. & Sharp, R. R., Jan 1 2023, In: Journal of Primary Care and Community Health. 14

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes after Return of Results

    Dikilitas, O., Sherafati, A., Saadatagah, S., Satterfield, B. A., Kochan, D. C., Anderson, K. C., Chung, W. K., Hebbring, S. J., Salvati, Z. M., Sharp, R. R., Sturm, A. C., Gibbs, R. A., Rowley, R., Venner, E., Linder, J. E., Jones, L. K., Perez, E. F., Peterson, J. F., Jarvik, G. P., Rehm, H. L., & 5 othersZouk, H., Roden, D. M., Williams, M. S., Manolio, T. A. & Kullo, I. J., Apr 1 2023, In: Circulation: Genomic and Precision Medicine. 16, 2, p. E003816

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection

    Ferar, K., Hall, T. O., Crawford, D. C., Rowley, R., Satterfield, B. A., Li, R., Gragert, L., Karlson, E. W., de Andrade, M., Kullo, I. J., McCarty, C. A., Kho, A., Hayes, M. G., Ritchie, M. D., Crane, P. K., Mirel, D. B., Carlson, C., Connolly, J. J., Hakonarson, H., Crenshaw, A. T., & 6 othersCarrell, D., Luo, Y., Dikilitas, O., Denny, J. C., Jarvik, G. P. & Crosslin, D. R., Dec 2023, In: Scientific reports. 13, 1, 18532.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

    Regeneron Genetics Center, UK Aneurysm Growth Study, DBDS Genomic Consortium, VA Million Veteran Program & DiscovEHR, Nov 2023, In: Nature Genetics. 55, 11, p. 1831-1842 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants

    Global Pulse Wave Velocity Study Group, Jun 2023, In: EBioMedicine. 92, 104619.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Heterozygous nonsense variants in laminin subunit 3α resulting in Ebstein's anomaly

    Zhou, Z., Huang, X., Tang, X., Chen, W., Chen, Q., Zhang, C., Li, Y., Zhao, D., Zheng, Z., Hu, S., Wang, J., Kullo, I. J. & Ding, K., Oct 12 2023, In: Human Genetics and Genomics Advances. 4, 4, 100227.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Impact of Complete Revascularization in the ISCHEMIA Trial

    ISCHEMIA Research Group, Sep 19 2023, In: Journal of the American College of Cardiology. 82, 12, p. 1175-1188 14 p.

    Research output: Contribution to journal › Article › peer-review

  • Polygenic Risk, Rare Variants, and Family History: Independent and Additive Effects on Coronary Heart Disease

    Saadatagah, S., Naderian, M., Dikilitas, O., Hamed, M. E., Bangash, H. & Kullo, I. J., Sep 2023, In: JACC: Advances. 2, 7, 100567.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

    Pividori, M., Lu, S., Li, B., Su, C., Johnson, M. E., Wei, W. Q., Feng, Q., Namjou, B., Kiryluk, K., Kullo, I. J., Luo, Y., Sullivan, B. D., Voight, B. F., Skarke, C., Ritchie, M. D., Grant, S. F. A. & Greene, C. S., Dec 2023, In: Nature communications. 14, 1, 5562.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Prospective, multi-site study of healthcare utilization after actionable monogenic findings from clinical sequencing

    Linder, J. E., Tao, R., Chung, W. K., Kiryluk, K., Liu, C., Weng, C., Connolly, J. J., Hakonarson, H., Harr, M., Leppig, K. A., Jarvik, G. P., Veenstra, D. L., Aufox, S., Chisholm, R. L., Gordon, A. S., Hoell, C., Rasmussen-Torvik, L. J., Smith, M. E., Holm, I. A., Miller, E. M., & 16 othersProws, C. A., Elskeally, O., Kullo, I. J., Lee, C., Jose, S., Manolio, T. A., Rowley, R., Padi-Adjirackor, N. A., Wilmayani, N. K., City, B., Wei, W. Q., Wiesner, G. L., Rahm, A. K., Williams, J. L., Williams, M. S. & Peterson, J. F., Nov 2 2023, In: American journal of human genetics. 110, 11, p. 1950-1958 9 p.

    Research output: Contribution to journal › Article › peer-review

  • Returning integrated genomic risk and clinical recommendations: The eMERGE study

    eMERGE Consortium, Apr 2023, In: Genetics in Medicine. 25, 4, 100006.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

    Gupta, Y., Friedman, D. J., McNulty, M. T., Khan, A., Lane, B., Wang, C., Ke, J., Jin, G., Wooden, B., Knob, A. L., Lim, T. Y., Appel, G. B., Huggins, K., Liu, L., Mitrotti, A., Stangl, M. C., Bomback, A., Westland, R., Bodria, M., Marasa, M., & 60 othersShang, N., Cohen, D. J., Crew, R. J., Morello, W., Canetta, P., Radhakrishnan, J., Martino, J., Liu, Q., Chung, W. K., Espinoza, A., Luo, Y., Wei, W. Q., Feng, Q., Weng, C., Fang, Y., Kullo, I. J., Naderian, M., Limdi, N., Irvin, M. R., Tiwari, H., Mohan, S., Rao, M., Dube, G. K., Chaudhary, N. S., Gutiérrez, O. M., Judd, S. E., Cushman, M., Lange, L. A., Lange, E. M., Bivona, D. L., Verbitsky, M., Winkler, C. A., Kopp, J. B., Santoriello, D., Batal, I., Pinheiro, S. V. B., Oliveira, E. A., Simoes e Silva, A. C., Pisani, I., Fiaccadori, E., Lin, F., Gesualdo, L., Amoroso, A., Ghiggeri, G. M., D’Agati, V. D., Magistroni, R., Kenny, E. E., Loos, R. J. F., Montini, G., Hildebrandt, F., Paul, D. S., Petrovski, S., Goldstein, D. B., Kretzler, M., Gbadegesin, R., Gharavi, A. G., Kiryluk, K., Sampson, M. G., Pollak, M. R. & Sanna-Cherchi, S., Dec 2023, In: Nature communications. 14, 1, 7836.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2022

    A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Million Veterans Program & Global Lipids Genetics Consortium, Aug 4 2022, In: American journal of human genetics. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A pragmatic clinical trial of cascade testing for familial hypercholesterolemia

    Miller, A. A., Bangash, H., Smith, C. Y., Wood-Wentz, C. M., Bailey, K. R. & Kullo, I. J., Dec 2022, In: Genetics in Medicine. 24, 12, p. 2535-2543 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study

    Glazer, A. M., Davogustto, G., Shaffer, C. M., Vanoye, C. G., Desai, R. R., Farber-Eger, E. H., Dikilitas, O., Shang, N., Pacheco, J. A., Yang, T., Muhammad, A., Mosley, J. D., Van Driest, S. L., Wells, Q. S., Shaffer, L. L., Kalash, O. R., Wada, Y., Bland, S., Yoneda, Z. T., Mitchell, D. W., & 30 othersKroncke, B. M., Kullo, I. J., Jarvik, G. P., Gordon, A. S., Larson, E. B., Manolio, T. A., Mirshahi, T., Luo, J. Z., Schaid, D., Namjou, B., Alsaied, T., Singh, R., Singhal, A., Liu, C., Weng, C., Hripcsak, G., Ralston, J. D., Mcnally, E. M., Chung, W. K., Carrell, D. S., Leppig, K. A., Hakonarson, H., Sleiman, P., Sohn, S., Glessner, J., Denny, J., Wei, W. Q., George, A. L., Shoemaker, M. B. & Roden, D. M., Mar 22 2022, In: Circulation. 145, 12, p. 877-891 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Clinical Applications Measuring Arterial Stiffness: An Expert Consensus for the Application of Cardio-Ankle Vascular Index

    Budoff, M. J., Alpert, B., Chirinos, J. A., Fernhall, B., Hamburg, N., Kario, K., Kullo, I., Matsushita, K., Miyoshi, T., Tanaka, H., Townsend, R. & Valensi, P., May 1 2022, In: American journal of hypertension. 35, 5, p. 441-453 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

    Ge, T., Irvin, M. R., Patki, A., Srinivasasainagendra, V., Lin, Y. F., Tiwari, H. K., Armstrong, N. D., Benoit, B., Chen, C. Y., Choi, K. W., Cimino, J. J., Davis, B. H., Dikilitas, O., Etheridge, B., Feng, Y. C. A., Gainer, V., Huang, H., Jarvik, G. P., Kachulis, C., Kenny, E. E., & 28 othersKhan, A., Kiryluk, K., Kottyan, L., Kullo, I. J., Lange, C., Lennon, N., Leong, A., Malolepsza, E., Miles, A. D., Murphy, S., Namjou, B., Narayan, R., O’Connor, M. J., Pacheco, J. A., Perez, E., Rasmussen-Torvik, L. J., Rosenthal, E. A., Schaid, D., Stamou, M., Udler, M. S., Wei, W. Q., Weiss, S. T., Ng, M. C. Y., Smoller, J. W., Lebo, M. S., Meigs, J. B., Limdi, N. A. & Karlson, E. W., Dec 2022, In: Genome medicine. 14, 1, 70.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

    Biobank Japan, EPIC-CVD & The CARDIoGRAMplusC4D Consortium, Dec 2022, In: Nature Genetics. 54, 12, p. 1803-1815 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Do research participants share genomic screening results with family members?

    Wynn, J., Milo Rasouly, H., Vasquez-Loarte, T., Saami, A. M., Weiss, R., Ziniel, S. I., Appelbaum, P. S., Wright Clayton, E., Christensen, K. D., Fasel, D., Green, R. C., Hain, H. S., Harr, M., Hoell, C., Kullo, I. J., Leppig, K. A., Myers, M. F., Pacyna, J. E., Perez, E. F., Prows, C. A., & 10 othersKulchak Rahm, A., Campbell-Salome, G., Sharp, R. R., Smith, M. E., Wiesner, G. L., Williams, J. L., Blout Zawatsky, C. L., Gharavi, A. G., Chung, W. K. & Holm, I. A., Apr 2022, In: Journal of Genetic Counseling. 31, 2, p. 447-458 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

    Regeneron Genetics Center, Dec 2022, In: Nature communications. 13, 1, 6914.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide polygenic score to predict chronic kidney disease across ancestries

    Khan, A., Turchin, M. C., Patki, A., Srinivasasainagendra, V., Shang, N., Nadukuru, R., Jones, A. C., Malolepsza, E., Dikilitas, O., Kullo, I. J., Schaid, D. J., Karlson, E., Ge, T., Meigs, J. B., Smoller, J. W., Lange, C., Crosslin, D. R., Jarvik, G. P., Bhatraju, P. K., Hellwege, J. N., & 19 othersChandler, P., Torvik, L. R., Fedotov, A., Liu, C., Kachulis, C., Lennon, N., Abul-Husn, N. S., Cho, J. H., Ionita-Laza, I., Gharavi, A. G., Chung, W. K., Hripcsak, G., Weng, C., Nadkarni, G., Irvin, M. R., Tiwari, H. K., Kenny, E. E., Limdi, N. A. & Kiryluk, K., Jul 2022, In: Nature Medicine. 28, 7, p. 1412-1420 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

    Wang, L., Scherer, S. E., Bielinski, S. J., Muzny, D. M., Jones, L. A., Black, J. L., Moyer, A. M., Giri, J., Sharp, R. R., Matey, E. T., Wright, J. A., Oyen, L. J., Nicholson, W. T., Wiepert, M., Sullard, T., Curry, T. B., Rohrer Vitek, C. R., McAllister, T. M., St. Sauver, J. L., Caraballo, P. J., & 102 othersLazaridis, K. N., Venner, E., Qin, X., Hu, J., Kovar, C. L., Korchina, V., Walker, K., Doddapaneni, H. V., Wu, T. J., Raj, R., Denson, S., Liu, W., Chandanavelli, G., Zhang, L., Wang, Q., Kalra, D., Karow, M. B., Harris, K. J., Sicotte, H., Peterson, S. E., Barthel, A. E., Moore, B. E., Skierka, J. M., Kluge, M. L., Kotzer, K. E., Kloke, K., Vander Pol, J. M., Marker, H., Sutton, J. A., Kekic, A., Ebenhoh, A., Bierle, D. M., Schuh, M. J., Grilli, C., Erickson, S., Umbreit, A., Ward, L., Crosby, S., Nelson, E. A., Levey, S., Elliott, M., Peters, S. G., Pereira, N., Frye, M., Shamoun, F., Goetz, M. P., Kullo, I. J., Wermers, R., Anderson, J. A., Formea, C. M., El Melik, R. M., Zeuli, J. D., Herges, J. R., Krieger, C. A., Hoel, R. W., Taraba, J. L., St. Thomas, S. R., Absah, I., Bernard, M. E., Fink, S. R., Gossard, A., Grubbs, P. L., Jacobson, T. M., Takahashi, P., Zehe, S. C., Buckles, S., Bumgardner, M., Gallagher, C., Fee-Schroeder, K., Nicholas, N. R., Powers, M. L., Ragab, A. K., Richardson, D. M., Stai, A., Wilson, J., Pacyna, J. E., Olson, J. E., Sutton, E. J., Beck, A. T., Horrow, C., Kalari, K. R., Larson, N. B., Liu, H., Wang, L., Lopes, G. S., Borah, B. J., Freimuth, R. R., Zhu, Y., Jacobson, D. J., Hathcock, M. A., Armasu, S. M., McGree, M. E., Jiang, R., Koep, T. H., Ross, J. L., Hilden, M. G., Bosse, K., Ramey, B., Searcy, I., Boerwinkle, E., Gibbs, R. A. & Weinshilboum, R. M., May 2022, In: Genetics in Medicine. 24, 5, p. 1062-1072 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., & 519 othersThorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q. P., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J. 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G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W. Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B. J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, YE. E., Ho, Y. L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K. M., Cho, K., O’Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Brown, C. D., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., Dec 2022, In: Genome biology. 23, 1, 268.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

    Regeneron Genetics Center, CARDIoGRAMplusC4D Consortium, Biobank Japan & Million Veteran Program, Aug 2022, In: Nature Medicine. 28, 8, p. 1679-1692 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders

    Zhang, X., Lucas, A. M., Veturi, Y., Drivas, T. G., Bone, W. P., Verma, A., Chung, W. K., Crosslin, D., Denny, J. C., Hebbring, S., Jarvik, G. P., Kullo, I., Larson, E. B., Rasmussen-Torvik, L. J., Schaid, D. J., Smoller, J. W., Stanaway, I. B., Wei, W. Q., Weng, C. & Ritchie, M. D., Dec 2022, In: Nature communications. 13, 1, 3428.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Multiancestral polygenic risk score for pediatric asthma

    The eMERGE Network, Nov 2022, In: Journal of Allergy and Clinical Immunology. 150, 5, p. 1086-1096 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Pathogenic variants in arteriopathy genes detected in a targeted sequencing study: Penetrance and 1-year outcomes after return of results

    Sherafati, A., Elsekaily, O., Saadatagah, S., Kochan, D. C., Lee, C., Wiesner, G. L., Liu, C., Dellefave-Castillo, L., Namjou, B., Perez, E. F., Salvati, Z. M., Connolly, J. J., Hakonarson, H., Williams, M. S., Jarvik, G. P., Chung, W. K., McNally, E. M., Manolio, T. A. & Kullo, I. J., Oct 2022, In: Genetics in Medicine. 24, 10, p. 2123-2133 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Penalized mediation models for multivariate data

    Schaid, D. J., Dikilitas, O., Sinnwell, J. P. & Kullo, I. J., Feb 2022, In: Genetic epidemiology. 46, 1, p. 32-50 19 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Polygenic scores in biomedical research

    Kullo, I. J., Lewis, C. M., Inouye, M., Martin, A. R., Ripatti, S. & Chatterjee, N., Sep 2022, In: Nature Reviews Genetics. 23, 9, p. 524-532 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics

    Robinson, J. R., Carroll, R. J., Bastarache, L., Chen, Q., Pirruccello, J., Mou, Z., Wei, W. Q., Connolly, J., Mentch, F., Crane, P. K., Hebbring, S. J., Crosslin, D. R., Gordon, A. S., Rosenthal, E. A., Stanaway, I. B., Hayes, M. G., Wei, W., Petukhova, L., Namjou-Khales, B., Zhang, G., & 15 othersSafarova, M. S., Walton, N. A., Still, C., Bottinger, E. P., Loos, R. J. F., Murphy, S. N., Jackson, G. P., Abumrad, N., Kullo, I. J., Jarvik, G. P., Larson, E. B., Weng, C., Roden, D., Khera, A. V. & Denny, J. C., Dec 2022, In: Obesity. 30, 12, p. 2477-2488 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US

    Saadatagah, S., Alhalabi, L., Farwati, M., Zordok, M., Bhat, A., Smith, C. Y., Wood-Wentz, C. M., Bailey, K. R. & Kullo, I. J., Dec 2022, In: American Journal of Preventive Cardiology. 12, 100393.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network

    Leppig, K. A., Kulchak Rahm, A., Appelbaum, P., Aufox, S., Bland, H. T., Buchanan, A., Christensen, K. D., Chung, W. K., Clayton, E. W., Crosslin, D., Denny, J., DeVange, S., Gordon, A., Green, R. C., Hakonarson, H., Harr, M. H., Henrikson, N., Hoell, C., Holm, I. A., Kullo, I. J., & 25 othersJarvik, G. P., Lammers, P. E., Larson, E. B., Lindor, N. M., Marasa, M., Myers, M. F., Perez, E., Peterson, J. F., Pratap, S., Prows, C. A., Ralston, J. D., Rasouly, H. M., Roden, D. M., Sharp, R. R., Singh, R., Shaibi, G., Smith, M. E., Sturm, A., Thiese, H. A., Van Driest, S. L., Williams, J., Williams, M. S., Wynn, J., Blout Zawatsky, C. L. & Wiesner, G. L., May 2022, In: Genetics in Medicine. 24, 5, p. 1130-1138 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Transgelin: A new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

    Lucero, D., Dikilitas, O., Mendelson, M. M., Aligabi, Z., Islam, P., Neufeld, E. B., Bansal, A. T., Freeman, L. A., Vaisman, B., Tang, J., Combs, C. A., Li, Y., Voros, S., Kullo, I. J. & Remaley, A. T., Jan 2022, In: Journal of Lipid Research. 63, 1, 100160.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Under-specification as the source of ambiguity and vagueness in narrative phenotype algorithm definitions

    Yu, J., Pacheco, J. A., Ghosh, A. S., Luo, Y., Weng, C., Shang, N., Benoit, B., Carrell, D. S., Carroll, R. J., Dikilitas, O., Freimuth, R. R., Gainer, V. S., Hakonarson, H., Hripcsak, G., Kullo, I. J., Mentch, F., Murphy, S. N., Peissig, P. L., Ramirez, A. H., Walton, N., & 2 othersWei, W. Q. & Rasmussen, L. V., Dec 2022, In: BMC Medical Informatics and Decision Making. 22, 1, 23.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroid

    Piekos, J. A., Hellwege, J. N., Zhang, Y., Torstenson, E. S., Jarvik, G. P., Dikilitas, O., Kullo, I. J., Schaid, D. J., Crosslin, D. R., Pendergrass, S. A., Lee, M. T. M., Roden, D., Denny, J. C., Edwards, T. L. & Velez Edwards, D. R., Nov 2022, In: Human genetics. 141, 11, p. 1739-1748 10 p.

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    Open Access

  • Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing

    Saad, M., El-Menyar, A., Kunji, K., Ullah, E., Al Suwaidi, J. & Kullo, I. J., Dec 1 2022, In: Circulation: Genomic and Precision Medicine. 15, 6, p. E003712

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation

    Bangash, H., Makkawy, A., Gundelach, J. H., Miller, A. A., Jacobson, K. A. & Kullo, I. J., Jan 1 2022, In: JMIR Human Factors. 9, 1, e32568.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2021

    Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort

    Rosenthal, E. A., Crosslin, D. R., Gordon, A. S., Carrell, D. S., Stanaway, I. B., Larson, E. B., Grafton, J., Wei, W. Q., Denny, J. C., Feng, Q. P., Shah, A. S., Sturm, A. C., Ritchie, M. D., Pacheco, J. A., Hakonarson, H., Rasmussen-Torvik, L. J., Connolly, J. J., Fan, X., Safarova, M., Kullo, I. J., & 1 othersJarvik, G. P., Dec 2021, In: BMC medical genomics. 14, 1, 11.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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