Molecular Pharmacology and Experimental Therapeutics

Research output

Research output per year 2005 2014 2018 2021 2022 2023 2024

• 53 Article
• 14 Conference contribution
• 9 Review article
• 3 Chapter
• 5 More
  • 2 Editorial
  • 2 Letter
  • 1 Comment/debate

Research output per year

Research output per year

Search results

• 2024

  Machine Learning Predicts Conversion from Normal Aging to Mild Cognitive Impairment Using Medical History, APOE Genotype, and Neuropsychological Assessment

  Prabhakaran, D., Grant, C., Pedraza, O., Caselli, R., Athreya, A. P. & Chandler, M., Mar 5 2024, In: Journal of Alzheimer's Disease. 98, 1, p. 83-94 12 p.

  Research output: Contribution to journal › Article › peer-review

  • cognitive impairment 100%
  • Machine Learning 92%
  • Cognitive Dysfunction 66%
  • Genotype 58%
  • learning 27%

• The Burnout PRedictiOn Using Wearable aNd ArtIficial IntelligEnce (BROWNIE) study: a decentralized digital health protocol to predict burnout in registered nurses

  Wilton, A. R., Sheffield, K., Wilkes, Q., Chesak, S., Pacyna, J., Sharp, R., Croarkin, P. E., Chauhan, M., Dyrbye, L. N., Bobo, W. V. & Athreya, A. P., Dec 2024, In: BMC Nursing. 23, 1, 114.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Artificial Intelligence 100%
  • Psychological Burnout 88%
  • Professional Burnout 70%
  • Nurses 54%
  • Health 36%

• Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing

  Turner, A. J., Haidar, C. E., Yang, W., Boone, E. C., Offer, S. M., Empey, P. E., Haddad, A., Tahir, S., Scharer, G., Broeckel, U. & Gaedigk, A., Jan 2024, In: Clinical and translational science. 17, 1, e13699.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Capecitabine 100%
  • Pharmacogenomic Testing 78%
  • 5-Fluorouracil 71%
  • Haplotypes 55%
  • Single Nucleotide Polymorphism 49%
• 2023

  BEDwARS: a robust Bayesian approach to bulk gene expression deconvolution with noisy reference signatures

  Ghaffari, S., Bouchonville, K. J., Saleh, E., Schmidt, R. E., Offer, S. M. & Sinha, S., Dec 2023, In: Genome biology. 24, 1, 178.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bayes Theorem 100%
  • gene expression 95%
  • deconvolution 87%
  • Gene Expression 49%
  • transcriptomics 36%

• Impact of Various Estimated Glomerular Filtration Rate Equations on the Pharmacokinetics of Meropenem in Critically Ill Adults

  Barreto, E. F., Chang, J., Rule, A. D., Mara, K. C., Meade, L. A., Paul, J., Jannetto, P. J., Athreya, A. P. & Scheetz, M. H., Dec 14 2023, In: Critical Care Explorations. 5, 12, p. E1011

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meropenem 100%
  • Glomerular Filtration Rate 77%
  • Critical Illness 75%
  • Pharmacokinetics 61%
  • Cystatin C 59%

• Machine Learning Identifies Smartwatch-Based Physiological Biomarker for Predicting Disruptive Behavior in Children: A Feasibility Study

  Mayo Clinic Inpatient Child and Adolescent Psychiatry Registered Nurse Staff, RN, Nov 1 2023, In: Journal of Child and Adolescent Psychopharmacology. 33, 9, p. 387-392 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Problem Behavior 92%
  • Feasibility Studies 92%
  • Biomarkers 57%
  • Child Behavior 48%

• Neurophenotypes of COVID-19: Risk factors and recovery outcomes

  Prabhakaran, D., Day, G. S., Munipalli, B., Rush, B. K., Pudalov, L., Niazi, S. K., Brennan, E., Powers, H. R., Durvasula, R., Athreya, A. & Blackmon, K., Jul 2023, In: Brain, Behavior, and Immunity - Health. 30, 100648.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Memory 46%
  • Cognition 37%
  • Unsupervised Machine Learning 28%
  • SARS Virus 23%

• PISTACHIo (PreemptIon of diSrupTive behAvior in CHIldren): real-time monitoring of sleep and behavior of children 3–7 years old receiving parent–child interaction therapy augment with artificial intelligence — the study protocol, pilot study

  Saliba, M., Drapeau, N., Skime, M., Hu, X., Accardi, C. J., Athreya, A. P., Kolacz, J., Shekunov, J., Jones, D. P., Croarkin, P. E. & Romanowicz, M., Dec 2023, In: Pilot and Feasibility Studies. 9, 1, 23.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Artificial Intelligence 100%
  • Polysomnography 84%
  • Child Behavior 82%
  • Problem Behavior 78%
  • Child 32%

• Population pharmacokinetic model of cefepime for critically ill adults: a comparative assessment of eGFR equations

  For the BLOOM Study Group, Nov 2023, In: Antimicrobial Agents and Chemotherapy. 67, 11

  Research output: Contribution to journal › Article › peer-review

  • Cefepime 100%
  • Glomerular Filtration Rate 70%
  • Critical Illness 69%
  • Cystatin C 56%
  • Pharmacokinetics 56%

• Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation

  Wen, Q., Zhou, J., Tian, C., Li, X., Song, G., Gao, Y., Sun, Y., Ma, C., Yao, S., Liang, X., Kang, X., Wang, N., Yao, Y., Wang, H., Liang, X., Tang, J., Offer, S. M., Lei, X., Yu, C., Liu, X., & 3 othersLiu, Z., Wang, Z. & Gan, H., Sep 2023, In: Nature Genetics. 55, 9, p. 1555-1566 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mouse Embryonic Stem Cells 100%
  • Histones 76%
  • Cell Differentiation 66%
  • Chromatids 29%
  • Embryonic Stem Cells 24%

• Withdrawal of antiseizure medications after MRI–Guided laser interstitial thermal therapy in extra-temporal lobe epilepsy

  Athreya, A., Matthews, R. E., Drane, D. L., Bonilha, L., Willie, J. T., Gross, R. E. & Karakis, I., Aug 2023, In: Seizure. 110, p. 86-92 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Temporal Lobe Epilepsy 100%
  • Lasers 69%
  • Seizures 66%
  • Hot Temperature 66%
  • Recurrence 20%
• 2022

  ACE2 and TMPRSS2 SARS-CoV-2 infectivity genes: deep mutational scanning and characterization of missense variants

  Zhang, L., Sarangi, V., Liu, D., Ho, M. F., Grassi, A. R., Wei, L., Moon, I., Vierkant, R. A., Larson, N. B., Lazaridis, K. N., Athreya, A. P., Wang, L. & Weinshilboum, R., Dec 15 2022, In: Human molecular genetics. 31, 24, p. 4183-4192 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • angiotensin converting enzyme 2 100%
  • Severe Acute Respiratory Syndrome 86%
  • Coronavirus 84%
  • Single Nucleotide Polymorphism 32%
  • Genes 27%

• A Characterization of the Clinical Global Impression Scale Thresholds in the Treatment of Adolescent Depression Across Multiple Rating Scales

  Zhang, C. Y., Voort, J. L. V., Yuruk, D., Mills, J. A., Emslie, G. J., Kennard, B. D., Mayes, T., Trivedi, M., Bobo, W. V., Strawn, J. R., Athreya, A. P. & Croarkin, P. E., Jun 1 2022, In: Journal of Child and Adolescent Psychopharmacology. 32, 5, p. 278-287 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Depression 100%
  • Child 51%
  • Self Report 44%
  • Benchmarking 36%
  • Equipment and Supplies 30%

• Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data

  Duong, S. Q., Crowson, C. S., Athreya, A., Atkinson, E. J., Davis, J. M., Warrington, K. J., Matteson, E. L., Weinshilboum, R., Wang, L. & Myasoedova, E., Dec 2022, In: Arthritis Research and Therapy. 24, 1, 162.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Blood Sedimentation 98%
  • Methotrexate 85%
  • Rheumatoid Arthritis 73%
  • Joints 62%

• Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling

  Li, X., Zhou, J., Zhao, W., Wen, Q., Wang, W., Peng, H., Gao, Y., Bouchonville, K. J., Offer, S. M., Chan, K., Wang, Z., Li, N. & Gan, H., Feb 2022, In: Genomics, Proteomics and Bioinformatics. 20, 1, p. 87-100 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antibody 100%
  • Staphylococcal Protein A 86%
  • Histone Code 85%
  • Histone 80%
  • Proximity 78%

• Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants

  Athreya, A. P., Vande Voort, J. L., Shekunov, J., Rackley, S. J., Leffler, J. M., McKean, A. J., Romanowicz, M., Kennard, B. D., Emslie, G. J., Mayes, T., Trivedi, M., Wang, L., Weinshilboum, R. M., Bobo, W. V. & Croarkin, P. E., Nov 2022, In: Journal of Child Psychology and Psychiatry and Allied Disciplines. 63, 11, p. 1347-1358 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Duloxetine Hydrochloride 99%
  • Fluoxetine 82%
  • Antidepressive Agents 79%
  • Placebos 61%

• Machine learning, pharmacogenomics, and clinical psychiatry: predicting antidepressant response in patients with major depressive disorder

  Bobo, W. V., Van Ommeren, B. & Athreya, A. P., 2022, In: Expert review of clinical pharmacology. 15, 8, p. 927-944 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Pharmacogenetics 100%
  • Machine Learning 99%
  • Major Depressive Disorder 91%
  • Antidepressive Agents 79%
  • Psychiatry 65%

• Multi-Omics Characterization of Early-and Adult-Onset Major Depressive Disorder

  Grant, C. W., Barreto, E. F., Kumar, R., Kaddurah-Daouk, R., Skime, M., Mayes, T., Carmody, T., Biernacka, J., Wang, L., Weinshilboum, R., Trivedi, M. H., Bobo, W. V., Croarkin, P. E. & Athreya, A. P., Mar 2022, In: Journal of Personalized Medicine. 12, 3, 412.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Major Depressive Disorder 100%
  • Age of Onset 72%
  • Genome-Wide Association Study 40%
  • Pharmacogenomic Testing 25%
  • Depression 25%

• Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder

  Grant, C. W., Wilton, A. R., Kaddurah-Daouk, R., Skime, M., Biernacka, J., Mayes, T., Carmody, T., Wang, L., Lazaridis, K., Weinshilboum, R., Bobo, W. V., Trivedi, M. H., Croarkin, P. E. & Athreya, A. P., Oct 3 2022, In: Frontiers in Pharmacology. 13, 984383.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Attempted Suicide 100%
  • Metabolomics 87%
  • Major Depressive Disorder 82%
  • Suicide 73%
  • Antidepressive Agents 71%

• Toward a Definition of “No Meaningful Benefit” From Antidepressant Treatment: An Equipercentile Analysis With Cross-Trial Validation Across Multiple Rating Scales

  Zhang, C., Virani, S., Mayes, T., Carmody, T., Croarkin, P. E., Weinshilboum, R., Rush, A. J., Trivedi, M., Athreya, A. P. & Bobo, W. V., 2022, In: Journal of Clinical Psychiatry. 83, 4, 21m14239.

  Research output: Contribution to journal › Article › peer-review

  • Antidepressive Agents 100%
  • Pharmacogenomic Testing 97%
  • Pharmacogenetics 84%
  • Citalopram 46%
  • Depression 24%

• Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis: A Pharmacogenomics-Driven Machine Learning Approach

  Pharmacogenetics of Methotrexate in Rheumatoid Arthritis Consortium, Jun 2022, In: Arthritis Care and Research. 74, 6, p. 879-888 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacogenetics 100%
  • Machine Learning 99%
  • Methotrexate 85%
  • Rheumatoid Arthritis 72%
  • Supervised Machine Learning 46%
• 2021

  An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes

  Ghaffari, S., Hanson, C., Schmidt, R. E., Bouchonville, K. J., Offer, S. M. & Sinha, S., Dec 2021, In: Genome biology. 22, 1, 19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • colorectal neoplasms 80%
  • metastasis 63%
  • cancer 62%
  • Colonic Neoplasms 60%
  • invasiveness 57%

• A pilot spectroscopy study of adversity in adolescents

  Sonmez, A. I., Lewis, C. P., Port, J. D., Athreya, A. P., Choi, D. S., Zaccariello, M. J., Shekunov, J., Blacker, C. J. & Croarkin, P. E., Dec 2021, In: Biomarkers in Neuropsychiatry. 5, 100043.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spectrum Analysis 100%
  • N-acetylaspartate 93%
  • Gyrus Cinguli 75%
  • Metabolite 71%
  • Spectroscopy 65%

• Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance

  Wang, Z., Wu, R., Nie, Q., Bouchonville, K. J., Diasio, R. B. & Offer, S. M., Mar 2021, In: Journal of the National Cancer Center. 1, 1, p. 15-22 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromatin Assembly Factor-1 100%
  • Drug Resistance 50%
  • Epigenomics 47%
  • Chromatin 32%
  • Lysine 17%

• Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity

  Hamzic, S., Schärer, D., Offer, S. M., Meulendijks, D., Nakas, C., Diasio, R. B., Fontana, S., Wehrli, M., Schürch, S., Amstutz, U. & Largiadèr, C. R., Aug 2021, In: British Journal of Clinical Pharmacology. 87, 8, p. 3234-3243 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 63%
  • Haplotypes 62%
  • dihydrouracil 30%
  • Alleles 24%

• Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

  Joyce, J. B., Grant, C. W., Liu, D., MahmoudianDehkordi, S., Kaddurah-Daouk, R., Skime, M., Biernacka, J., Frye, M. A., Mayes, T., Carmody, T., Croarkin, P. E., Wang, L., Weinshilboum, R., Bobo, W. V., Trivedi, M. H. & Athreya, A. P., Dec 2021, In: Translational psychiatry. 11, 1, 513.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute-Phase Reaction 100%
  • Machine Learning 90%
  • Citalopram 75%
  • Antidepressive Agents 72%
  • Single Nucleotide Polymorphism 58%

• Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings

  Athreya, A. P., Brückl, T., Binder, E. B., John Rush, A., Biernacka, J., Frye, M. A., Neavin, D., Skime, M., Monrad, D., Iyer, R. K., Mayes, T., Trivedi, M., Carter, R. E., Wang, L., Weinshilboum, R. M., Croarkin, P. E. & Bobo, W. V., Jun 2021, In: Neuropsychopharmacology. 46, 7, p. 1272-1282 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Statistical Models 100%
  • Antidepressive Agents 80%
  • Serotonin Uptake Inhibitors 78%
  • Depression 46%
  • Pharmaceutical Preparations 36%

• Withdrawal of antiepileptic drugs after stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy

  Athreya, A., Fasano, R. E., Drane, D. L., Millis, S. R., Willie, J. T., Gross, R. E. & Karakis, I., Oct 2021, In: Epilepsy Research. 176, 106721.

  Research output: Contribution to journal › Article › peer-review

  • Temporal Lobe Epilepsy 100%
  • Anticonvulsants 80%
  • Lasers 69%
  • Seizures 44%
  • Recurrence 16%
• 2020

  A novel nomenclature for repeat motifs in the thymidylate synthase enhancer region and its relevance for pharmacogenetic studies

  Schaerer, D., Froehlich, T. K., Hamzic, S., Offer, S. M., Diasio, R. B., Joerger, M., Amstutz, U. & Largiadèr, C. R., Dec 2020, In: Journal of Personalized Medicine. 10, 4, p. 1-13 13 p., 181.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thymidylate Synthase 100%
  • Pharmacogenomic Testing 99%
  • Terminology 75%
  • Fluorouracil 72%
  • Upstream Stimulatory Factors 30%

• Real-world experiences with acupuncture among breast cancer survivors: a cross-sectional survey study

  Zayas, J., Ruddy, K. J., Olson, J. E., Couch, F. J., Bauer, B. A., Mallory, M. J., Yang, P., Zahrieh, D., Athreya, A. P., Loprinzi, C. L. & Cathcart-Rake, E. J., Dec 2020, In: Supportive Care in Cancer. 28, 12, p. 5833-5838 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cancer Survivors 100%
  • Acupuncture 98%
  • Cross-Sectional Studies 59%
  • Breast Neoplasms 58%
  • Breast Diseases 37%
  2 Scopus citations

• Severe capecitabine toxicity associated with a rare DPYD variant identified through whole-genome sequencing

  Ly, R. C., Schmidt, R. E., Kiel, P. J., Pratt, V. M., Schneider, B. P., Radovich, M., Offer, S. M., Diasio, R. B. & Skaar, T. C., 2020, In: JCO Precision Oncology. 4, p. 632-638 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Scopus citations
• 2019

  Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication

  Athreya, A. P., Neavin, D., Carrillo-Roa, T., Skime, M., Biernacka, J., Frye, M. A., Rush, A. J., Wang, L., Binder, E. B., Iyer, R. K., Weinshilboum, R. M. & Bobo, W. V., Oct 1 2019, In: Clinical pharmacology and therapeutics. 106, 4, p. 855-865 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacogenetics 100%
  • Machine Learning 99%
  • Serotonin Uptake Inhibitors 96%
  • Antidepressive Agents 79%
  • Major Depressive Disorder 68%
  22 Scopus citations
• 2018

  Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

  Athreya, A., Iyer, R., Neavin, D., Wang, L., Weinshilboum, R., Kaddurah-Daouk, R., Rush, J., Frye, M. & Bobo, W., Aug 2018, In: IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psychiatry 100%
  • Predictability 96%
  • Augmentation 84%
  • Disorder 81%
  • Drugs 73%
  14 Scopus citations

• Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

  Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K., & 4 othersWang, L., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In: Translational psychiatry. 8, 1, 56.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • beta-Defensins 100%
  • Kynurenine 92%
  • Aryl Hydrocarbon Receptors 88%
  • Metabolomics 75%
  • Major Depressive Disorder 71%
  22 Scopus citations

• Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

  Amstutz, U., Henricks, L. M., Offer, S. M., Barbarino, J., Schellens, J. H. M., Swen, J. J., Klein, T. E., McLeod, H. L., Caudle, K. E., Diasio, R. B. & Schwab, M., Feb 2018, In: Clinical pharmacology and therapeutics. 103, 2, p. 210-216 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Pharmacogenetics 75%
  • Genotype 47%
  • Guidelines 42%
  • Capecitabine 28%
  157 Scopus citations

• Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

  Shrestha, S., Zhang, C., Jerde, C. R., Nie, Q., Li, H., Offer, S. M. & Diasio, R. B., Oct 2018, In: Clinical pharmacology and therapeutics. 104, 4, p. 709-718 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 63%
  • Alleles 48%
  • Machine Learning 37%
  • Precision Medicine 35%
  16 Scopus citations

• Machine learning helps identify new drug mechanisms in triple-negative breast cancer

  Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L., Kalbarczyk, Z. T. & Iyer, R. K., Jul 2018, In: IEEE Transactions on Nanobioscience. 17, 3, p. 251-259 9 p., 8401331.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metformin 100%
  • Triple Negative Breast Neoplasms 84%
  • Machine Learning 79%
  • Genes 66%
  • Machine learning 51%
  3 Scopus citations
• 2017

  Model-based unsupervised learning informs metformininduced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

  Athreya, A. P., Kalari, K. R., Cairns, J., Gaglio, A. J., Wills, Q. F., Niu, N., Weinshilboum, R., Iyer, R. K. & Wang, L., 2017, In: Oncotarget. 8, 16, p. 27199-27215 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Migration Inhibition 100%
  • Metformin 74%
  • Learning 50%
  • Breast Neoplasms 43%
  • Genes 11%
  8 Scopus citations

• Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5-Fluorouracil Sensitivity in an East African Population

  Elraiyah, T., Jerde, C. R., Shrestha, S., Wu, R., Nie, Q., Giama, N. H., Sarangi, V., Roberts, L. R., Offer, S. M. & Diasio, R. B., Mar 1 2017, In: Clinical pharmacology and therapeutics. 101, 3, p. 382-390 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 63%
  • Clinical Studies 30%
  • Population 26%
  • Pharmacogenetics 25%
  16 Scopus citations

• Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

  Nie, Q., Shrestha, S., Tapper, E. E., Trogstad-Isaacson, C. S., Bouchonville, K. J., Lee, A. M., Wu, R., Jerde, C. R., Wang, Z., Kubica, P. A., Offer, S. M. & Diasio, R. B., Oct 2017, In: Clinical pharmacology and therapeutics. 102, 4, p. 662-670 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Alternative Splicing 72%
  • Fluorouracil 42%
  • Messenger RNA 38%
  • Enzymes 36%
  22 Scopus citations
• 2016

  A phosphotyrosine switch regulates organic cation transporters

  Sprowl, J. A., Ong, S. S., Gibson, A. A., Hu, S., Du, G., Lin, W., Li, L., Bharill, S., Ness, R. A., Stecula, A., Offer, S. M., Diasio, R. B., Nies, A. T., Schwab, M., Cavaletti, G., Schlatter, E., Ciarimboli, G., Schellens, J. H. M., Isacoff, E. Y., Sali, A., & 4 othersChen, T., Baker, S. D., Sparreboom, A. & Pabla, N., Mar 16 2016, In: Nature communications. 7, 10880.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • transporter 100%
  • tyrosine 98%
  • Tyrosine Kinase Inhibitor 98%
  • Phosphotyrosine 89%
  • Organic Cation 82%
  58 Scopus citations

• Histone H3K27 trimethylation modulates 5-fluorouracil resistance by inhibiting PU.1 binding to the DPYD promoter

  Wu, R., Nie, Q., Tapper, E. E., Jerde, C. R., Dunlap, G. S., Shrestha, S., Elraiyah, T. A., Offer, S. M. & Diasio, R. B., Nov 1 2016, In: Cancer research. 76, 21, p. 6362-6373 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 95%
  • Histones 93%
  • proto-oncogene protein Spi-1 27%
  • Antimetabolites 22%
  8 Scopus citations
• 2015

  Polymorphisms in MIR27A associated with early-onset toxicity in fluoropyrimidine-based chemotherapy

  Amstutz, U., Offer, S. M., Sistonen, J., Joerger, M., Diasio, R. B. & Largiader, C. R., May 1 2015, In: Clinical Cancer Research. 21, 9, p. 2038-2044 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Drug Therapy 78%
  • Confidence Intervals 15%
  • MicroRNAs 11%
  • Research Design 10%
  29 Scopus citations
• 2014

  A DPYD variant (y186c) specific to individuals of african descent in a patient with life-threatening 5-fu toxic effects: Potential for an individualized medicine approach

  Saif, M. W., Lee, A. M., Offer, S. M., McConnell, K., Relias, V. & Diasio, R. B., Jan 2014, In: Mayo Clinic proceedings. 89, 1, p. 131-136 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Precision Medicine 100%
  • Fluorouracil 88%
  • Dihydrouracil Dehydrogenase (NADP) 79%
  • Poisons 68%
  • African Americans 24%
  18 Scopus citations

• Comparative functional analysis of dpyd variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity

  Offer, S. M., Fossum, C. C., Wegner, N. J., Stuflesser, A. J., Butterfield, G. L. & Diasio, R. B., Jan 5 2014, In: Cancer research. 74, 9, p. 2545-2554 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 63%
  • Enzymes 27%
  • Clinical Studies 11%
  • Uracil 10%
  98 Scopus citations

• Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: Implications for epigenetic therapy

  Witzig, T. E., Hu, G., Offer, S. M., Wellik, L. E., Han, J. J., Stenson, M. J., Dogan, A., Diasio, R. B. & Gupta, M., 2014, In: Leukemia. 28, 1, p. 147-154 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • protein phosphatase 6 100%
  • Protein Tyrosine Phosphatases 62%
  • Panobinostat 60%
  • Lymphoma, Large B-Cell, Diffuse 57%
  • Epigenomics 44%
  21 Scopus citations

• microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites

  Offer, S. M., Butterfield, G. L., Jerde, C. R., Fossum, C. C., Wegner, N. J. & Diasio, R. B., Mar 2014, In: Molecular cancer therapeutics. 13, 3, p. 742-751 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Fluorouracil 63%
  • MicroRNAs 56%
  • Binding Sites 51%
  • Enzymes 36%
  54 Scopus citations
• 2013

  A DPYD variant (Y186C) in individuals of african ancestry is associated with reduced DPD enzyme activity

  Offer, S. M., Lee, A. M., Mattison, L. K., Fossum, C., Wegner, N. J. & Diasio, R. B., Jul 2013, In: Clinical pharmacology and therapeutics. 94, 1, p. 158-166 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fluorouracil 100%
  • African Americans 73%
  • Enzymes 57%
  • Dihydrouracil Dehydrogenase (NADP) 39%
  • Volunteers 21%
  52 Scopus citations

• Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity

  Offer, S. M., Wegner, N. J., Fossum, C., Wang, K. & Diasio, R. B., Mar 15 2013, In: Cancer research. 73, 6, p. 1958-1968 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fluorouracil 100%
  • Enzymes 57%
  • In Vitro Techniques 45%
  • Genetic Variation 25%
  • Dihydrouracil Dehydrogenase (NADP) 19%
  72 Scopus citations
• 2011

  Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: A retrospective cohort study of the Eastern Cooperative Oncology Group

  Yoon, H. H., Catalano, P. J., Murphy, K. M., Skaar, T. C., Philips, S., Powell, M., Montgomery, E. A., Hafez, M. J., Offer, S. M., Liu, G., Meltzer, S. J., Wu, X., Forastiere, A. A., Benson, A. B., Kleinberg, L. R. & Gibson, M. K., May 17 2011, In: BMC cancer. 11, 176.

  Research output: Contribution to journal › Article › peer-review

  • Chemoradiotherapy 100%
  • Genetic Variation 90%
  • DNA Repair 86%
  • Single Nucleotide Polymorphism 78%
  • Adenocarcinoma 73%
  24 Scopus citations