TY - JOUR
T1 - Workshop on the characterization of fiber-based scaffolds
T2 - Challenges, progress, and future directions
AU - Garcia, Lexi
AU - Soliman, Sherif
AU - Francis, Michael P.
AU - Yaszemski, Michael J.
AU - Doshi, Jayesh
AU - Simon, Carl G.
AU - Robinson-Zeigler, Rebecca
N1 - Funding Information:
The authors thank the speakers and attendees for their participation in making the workshop a success. The authors also thank Dawn Henke from Standards Coordinating Body and Kate Chalfin from ASTM for their assistance in organizing the workshop. This is an official contribution of the National Institute of Standards and Technology (NIST) and is not subject to copyright in the United States. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIST.
Publisher Copyright:
Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - A critical component of many tissue-engineered medical products (TEMPs) is the scaffold or biomaterial. The industry's understanding of scaffold properties and their influence on cell behavior has advanced, but our technical capability to reliably characterize scaffolds requires improvement, especially to enable large-scale manufacturing. In response to the key findings from the 2013 ASTM International Workshop of Standards and Measurements for Tissue Engineering Scaffolds, the National Institute of Standards and Technology (NIST), ASTM International, BiofabUSA, and the Standards Coordinating Body (SCB) organized a workshop in 2018 titled, “Characterization of Fiber-Based Scaffolds”. The goal was to convene a group of 40 key industry stakeholders to identify major roadblocks in measurements of fiber-based scaffold properties. This report provides an overview of the findings from this collaborative workshop. The four major consensus findings were that (a) there is need for a documentary standard guide that would aid developers in the selection of test methods for characterizing fiber-based scaffolds; (b) there is a need for a strategy to assess the quality of porosity and pore size measurements, which could potentially be ameliorated by the development of a reference material; (b) there are challenges with the lexicon used to describe and assess scaffolds; and (d) the vast array of product applications makes it challenging to identify consensus test methods. As a result of these findings, a working group was formed to develop an ASTM Standard Guide for Characterizing Fiber-Based Constructs that will provide developers guidance on selecting measurements for characterizing fiber-based scaffolds.
AB - A critical component of many tissue-engineered medical products (TEMPs) is the scaffold or biomaterial. The industry's understanding of scaffold properties and their influence on cell behavior has advanced, but our technical capability to reliably characterize scaffolds requires improvement, especially to enable large-scale manufacturing. In response to the key findings from the 2013 ASTM International Workshop of Standards and Measurements for Tissue Engineering Scaffolds, the National Institute of Standards and Technology (NIST), ASTM International, BiofabUSA, and the Standards Coordinating Body (SCB) organized a workshop in 2018 titled, “Characterization of Fiber-Based Scaffolds”. The goal was to convene a group of 40 key industry stakeholders to identify major roadblocks in measurements of fiber-based scaffold properties. This report provides an overview of the findings from this collaborative workshop. The four major consensus findings were that (a) there is need for a documentary standard guide that would aid developers in the selection of test methods for characterizing fiber-based scaffolds; (b) there is a need for a strategy to assess the quality of porosity and pore size measurements, which could potentially be ameliorated by the development of a reference material; (b) there are challenges with the lexicon used to describe and assess scaffolds; and (d) the vast array of product applications makes it challenging to identify consensus test methods. As a result of these findings, a working group was formed to develop an ASTM Standard Guide for Characterizing Fiber-Based Constructs that will provide developers guidance on selecting measurements for characterizing fiber-based scaffolds.
KW - documentary standards
KW - scaffolds
KW - tissue engineering
KW - workshop report
UR - http://www.scopus.com/inward/record.url?scp=85077140378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077140378&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.34545
DO - 10.1002/jbm.b.34545
M3 - Article
C2 - 31880376
AN - SCOPUS:85077140378
SN - 1552-4973
VL - 108
SP - 2063
EP - 2072
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
IS - 5
ER -