Wnt signaling in lung organogenesis

Stijn P. De Langhe; Susan D. Reynolds

doi:10.4161/org.4.2.5856

Wnt signaling in lung organogenesis

Stijn P. De Langhe, Susan D. Reynolds

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Reporter transgene, knockout, and misexpression studies support the notion that Wnt/β-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, β-catenin and the Wnt/β-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/β-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/β-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.

Original language	English (US)
Pages (from-to)	100-108
Number of pages	9
Journal	Organogenesis
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/org.4.2.5856
State	Published - 2008

Keywords

Airway
Alveolar
Endoderm
Mesenchyme
Morphogenesis
Respiratory

ASJC Scopus subject areas

Biomedical Engineering
Embryology
Developmental Biology
Transplantation

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10.4161/org.4.2.5856

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title = "Wnt signaling in lung organogenesis",

abstract = "Reporter transgene, knockout, and misexpression studies support the notion that Wnt/β-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, β-catenin and the Wnt/β-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/β-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/β-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.",

keywords = "Airway, Alveolar, Endoderm, Mesenchyme, Morphogenesis, Respiratory",

author = "{De Langhe}, {Stijn P.} and Reynolds, {Susan D.}",

note = "Funding Information: This work was supported by a N.T.H. R.O. grant (HL075585-03) and a Cystic Fibrosis Foundation grant to S.D.R.",

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AU - De Langhe, Stijn P.

AU - Reynolds, Susan D.

N1 - Funding Information: This work was supported by a N.T.H. R.O. grant (HL075585-03) and a Cystic Fibrosis Foundation grant to S.D.R.

PY - 2008

Y1 - 2008

N2 - Reporter transgene, knockout, and misexpression studies support the notion that Wnt/β-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, β-catenin and the Wnt/β-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/β-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/β-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.

AB - Reporter transgene, knockout, and misexpression studies support the notion that Wnt/β-catenin signaling regulates aspects of branching morphogenesis, regional specialization of the epithelium and mesenchyme, and establishment of progenitor cell pools. As demonstrated for other foregut endoderm-derived organs, β-catenin and the Wnt/β-catenin signaling pathway contribute to control of cellular proliferation, differentiation and migration. However, the contribution of Wnt/β-catenin signaling to these processes is shaped by other signals impinging on target tissues. In this review, we will concentrate on roles for Wnt/β-catenin in respiratory system development, including segregation of the conducting airway and alveolar compartments, specialization of the mesenchyme, and establishment of tracheal asymmetries and tracheal glands.

KW - Airway

KW - Alveolar

KW - Endoderm

KW - Mesenchyme

KW - Morphogenesis

KW - Respiratory

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JO - Organogenesis

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Wnt signaling in lung organogenesis

Abstract

Keywords

ASJC Scopus subject areas

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