Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS

Abed Benbuk; Daniel Gulick; Diogo Moniz-Garcia; Shiyi Liu; Alfredo Quinones-Hinojosa; Jennifer Blain Christen

doi:10.1109/MWSCAS57524.2023.10406024

Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS

Abed Benbuk, Daniel Gulick, Diogo Moniz-Garcia, Shiyi Liu, Alfredo Quinones-Hinojosa, Jennifer Blain Christen

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this paper, we describe the design and in-vivo testing of a wireless, battery-free implant that is fabricated on a 100 μ m-thick parylene/PDMS substrate with dimensions of 15.6 ×6.6 mm2. The benchtop test shows that the device can generate monophasic voltage pulses with an amplitude of 20 V at a distance of 25 mm from an RF transmitter, and the frequency and width of these pulses can be externally controlled. The implant's operation was verified in-vivo by generating high-amplitude voltage pulses (8 V) and injecting adequate current (≈ 2 mA) into the motor cortex, leading to a motor response in a rat model. These results demonstrate the implant's ability to eliminate the need for batteries and wires and deliver electrical stimulation.

Original language	English (US)
Title of host publication	2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	768-772
Number of pages	5
ISBN (Electronic)	9798350302103
DOIs	https://doi.org/10.1109/MWSCAS57524.2023.10406024
State	Published - 2023
Event	2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023 - Tempe, United States Duration: Aug 6 2023 → Aug 9 2023

Publication series

Name	Midwest Symposium on Circuits and Systems
ISSN (Print)	1548-3746

Conference

Conference	2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023
Country/Territory	United States
City	Tempe
Period	8/6/23 → 8/9/23

Keywords

Battery-free
Biocompatible
Cortical Stimulation
Implant
Wireless power transfer (WPT)

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Access to Document

10.1109/MWSCAS57524.2023.10406024

Cite this

Benbuk, A., Gulick, D., Moniz-Garcia, D., Liu, S., Quinones-Hinojosa, A., & Christen, J. B. (2023). Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS. In 2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023 (pp. 768-772). (Midwest Symposium on Circuits and Systems). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MWSCAS57524.2023.10406024

Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS. / Benbuk, Abed; Gulick, Daniel; Moniz-Garcia, Diogo et al.
2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 768-772 (Midwest Symposium on Circuits and Systems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Benbuk, A, Gulick, D, Moniz-Garcia, D, Liu, S, Quinones-Hinojosa, A & Christen, JB 2023, Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS. in 2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023. Midwest Symposium on Circuits and Systems, Institute of Electrical and Electronics Engineers Inc., pp. 768-772, 2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023, Tempe, United States, 8/6/23. https://doi.org/10.1109/MWSCAS57524.2023.10406024

Benbuk A, Gulick D, Moniz-Garcia D, Liu S, Quinones-Hinojosa A, Christen JB. Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS. In 2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 768-772. (Midwest Symposium on Circuits and Systems). doi: 10.1109/MWSCAS57524.2023.10406024

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abstract = "In this paper, we describe the design and in-vivo testing of a wireless, battery-free implant that is fabricated on a 100 μ m-thick parylene/PDMS substrate with dimensions of 15.6 ×6.6 mm2. The benchtop test shows that the device can generate monophasic voltage pulses with an amplitude of 20 V at a distance of 25 mm from an RF transmitter, and the frequency and width of these pulses can be externally controlled. The implant's operation was verified in-vivo by generating high-amplitude voltage pulses (8 V) and injecting adequate current (≈ 2 mA) into the motor cortex, leading to a motor response in a rat model. These results demonstrate the implant's ability to eliminate the need for batteries and wires and deliver electrical stimulation.",

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AU - Quinones-Hinojosa, Alfredo

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AB - In this paper, we describe the design and in-vivo testing of a wireless, battery-free implant that is fabricated on a 100 μ m-thick parylene/PDMS substrate with dimensions of 15.6 ×6.6 mm2. The benchtop test shows that the device can generate monophasic voltage pulses with an amplitude of 20 V at a distance of 25 mm from an RF transmitter, and the frequency and width of these pulses can be externally controlled. The implant's operation was verified in-vivo by generating high-amplitude voltage pulses (8 V) and injecting adequate current (≈ 2 mA) into the motor cortex, leading to a motor response in a rat model. These results demonstrate the implant's ability to eliminate the need for batteries and wires and deliver electrical stimulation.

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Wireless Stimulation of Motor Cortex Using an Ultra-Thin Implant Fabricated on Parylene/PDMS

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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