TY - JOUR
T1 - Wireless Stimulation of Motor Cortex Through a Collagen Dura Substitute Using an Ultra-Thin Implant Fabricated on Parylene/PDMS
AU - Benbuk, Abed
AU - Gulick, Daniel
AU - Moniz-Garcia, Diogo
AU - Liu, Shiyi
AU - Quinones-Hinojosa, Alfredo
AU - Christen, Jennifer Blain
N1 - Publisher Copyright:
© 2023 The Authors.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - We present the design, fabrication, and in vivo testing of an ultra-thin (100 µm) wireless and battery-free implant for stimulation of the brain’s cortex. The implant is fabricated on a flexible and transparent parylene/PDMS substrate, and it is miniaturized to dimensions of 15.6 × 6.6 mm2. The frequency and pulse width of the monophasic voltage pulses are determined through On-Off keying (OOK) modulation of a wireless transmission at 2.45 GHz. Furthermore, the implant triggered a motor response in vivo when tested in 6 rodents. Limb response was observed by wireless stimulation of the brain’s motor cortex through an FDA-approved collagen dura substitute that was placed on the dura in the craniotomy site, with no direct contact between the implant’s electrodes and the brain’s cortical surface. Therefore, the wireless stimulation method reported herein enables the concept of an e-dura substitute, where wireless electronics can be integrated onto a conventional dura substitute to augment its therapeutic function and administer any desired stimulation protocol without the need for post-surgical intervention for battery replacement or reprogramming stimulation parameters.
AB - We present the design, fabrication, and in vivo testing of an ultra-thin (100 µm) wireless and battery-free implant for stimulation of the brain’s cortex. The implant is fabricated on a flexible and transparent parylene/PDMS substrate, and it is miniaturized to dimensions of 15.6 × 6.6 mm2. The frequency and pulse width of the monophasic voltage pulses are determined through On-Off keying (OOK) modulation of a wireless transmission at 2.45 GHz. Furthermore, the implant triggered a motor response in vivo when tested in 6 rodents. Limb response was observed by wireless stimulation of the brain’s motor cortex through an FDA-approved collagen dura substitute that was placed on the dura in the craniotomy site, with no direct contact between the implant’s electrodes and the brain’s cortical surface. Therefore, the wireless stimulation method reported herein enables the concept of an e-dura substitute, where wireless electronics can be integrated onto a conventional dura substitute to augment its therapeutic function and administer any desired stimulation protocol without the need for post-surgical intervention for battery replacement or reprogramming stimulation parameters.
KW - Battery-free
KW - Wireless Power Transfer (WPT)
KW - brain
KW - cortical stimulation
KW - dura substitute
KW - e-dura
KW - implant
KW - wireless
UR - http://www.scopus.com/inward/record.url?scp=85181834043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85181834043&partnerID=8YFLogxK
U2 - 10.1109/TBCAS.2023.3329447
DO - 10.1109/TBCAS.2023.3329447
M3 - Article
AN - SCOPUS:85181834043
SN - 1932-4545
VL - 18
SP - 334
EP - 346
JO - IEEE Transactions on Biomedical Circuits and Systems
JF - IEEE Transactions on Biomedical Circuits and Systems
IS - 2
M1 - 10304332
ER -