Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

Douglas F. Easton; Daniel J. Schaid; Alice S. Whittemore; William J. Isaacs

doi:10.1002/pros.10300

Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

Douglas F. Easton, Daniel J. Schaid, Alice S. Whittemore, William J. Isaacs

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

90 Scopus citations

Abstract

BACKGROUND. There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS. We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS. Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS. These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

Original language	English (US)
Pages (from-to)	261-269
Number of pages	9
Journal	Prostate
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/pros.10300
State	Published - Dec 1 2003

Keywords

Genetic linkage analysis
ICPCG
Non-parametric linkage
Parametric linkage
Prostate cancer susceptibility

ASJC Scopus subject areas

Oncology
Urology

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10.1002/pros.10300

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title = "Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches",

abstract = "BACKGROUND. There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS. We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS. Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS. These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.",

keywords = "Genetic linkage analysis, ICPCG, Non-parametric linkage, Parametric linkage, Prostate cancer susceptibility",

author = "Easton, {Douglas F.} and Schaid, {Daniel J.} and Whittemore, {Alice S.} and Isaacs, {William J.}",

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TY - JOUR

T1 - Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

AU - Easton, Douglas F.

AU - Schaid, Daniel J.

AU - Whittemore, Alice S.

AU - Isaacs, William J.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - BACKGROUND. There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS. We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS. Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS. These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

AB - BACKGROUND. There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS. We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS. Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS. These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

KW - Genetic linkage analysis

KW - ICPCG

KW - Non-parametric linkage

KW - Parametric linkage

KW - Prostate cancer susceptibility

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DO - 10.1002/pros.10300

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JO - Prostate

JF - Prostate

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ER -

Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

Abstract

Keywords

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