What to do With Wake-Up Stroke

Mark N. Rubin, Kevin M. Barrett

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Wake-up stroke, defined as the situation where a patient awakens with stroke symptoms that were not present prior to falling asleep, represents roughly 1 in 5 acute ischemic strokes and remains a therapeutic dilemma. Patients with wake-up stroke were excluded from most ischemic stroke treatment trials and are often not eligible for acute reperfusion therapy in clinical practice, leading to poor outcomes. Studies of neuroimaging with standard noncontrast computed tomography (CT), magnetic resonance imaging (MRI), and multimodal perfusion-based CT and MRI suggest wake-up stroke may occur shortly before awakening and may assist in selecting patients for acute reperfusion therapies. Pilot studies of wake-up stroke treatment based on these neuroimaging features are promising but have limited generalizability. Ongoing randomized treatment trials using neuroimaging-based patient selection may identify a subset of patients with wake-up stroke that can safely benefit from acute reperfusion therapies.

Original languageEnglish (US)
Pages (from-to)161-172
Number of pages12
JournalThe Neurohospitalist
Issue number3
StatePublished - Jul 2015


  • acute stroke
  • hemorrhage
  • outcome
  • tPA
  • thrombolysis
  • wake-up stroke

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'What to do With Wake-Up Stroke'. Together they form a unique fingerprint.

Cite this