What Is New in Low Gradient Aortic Stenosis: Surgery, TAVR, or Medical Therapy?

Vidhu Anand, Sunil V. Mankad, Mackram Eleid

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: A significant proportion of patients with aortic stenosis (AS) have discordance in severity by mean gradient/peak velocity and aortic valve area. Low gradient aortic stenosis (LG-AS) is defined when the aortic valve area is < 1 cm2 consistent with severe AS and mean aortic gradient is < 40 mmHg consistent with non-severe AS. LG-AS represents a diagnostic and therapeutic challenge. Purpose of Review: To summarize the different categories, diagnosis, management, and prognosis of LG-AS. LG-AS is classified as classical (ejection fraction (EF) < 50%, indexed stroke volume (SVi) < 35 ml/m2), paradoxical (EF > 50%, SVi < 35 ml/m2), pseudo-severe (moderate AS with reduced EF), or normal flow low gradient AS. Recent Findings: Recent findings emphasize the importance of low-dose dobutamine stress echocardiography and CT calcium score in the assessment of aortic valve. In addition, flow reserve (increase in SV > 50%) can be evaluated during dobutamine stress echocardiography and helps predict perioperative prognosis. Summary: Patients with LG-AS have better survival with aortic valve replacement (AVR) compared to medical therapy, irrespective of presence or absence of flow reserve. Some recent studies suggest that transcatheter aortic valve replacement (TAVR) may be superior to surgical AVR for patients with a lack of contractile flow reserve or those with paradoxical LG-AS, but further investigation is needed to clarify optimal treatment. The role of TAVR in patients with moderate AS and reduced EF is also under investigation.

Original languageEnglish (US)
Article number78
JournalCurrent cardiology reports
Issue number9
StatePublished - Sep 1 2020


  • Dobutamine stress echocardiography
  • Flow reserve
  • Low gradient aortic stenosis
  • Transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'What Is New in Low Gradient Aortic Stenosis: Surgery, TAVR, or Medical Therapy?'. Together they form a unique fingerprint.

Cite this