What do I need to know about immunoglobulin light chain (AL) amyloidosis?

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98 Scopus citations


Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction.

Original languageEnglish (US)
Pages (from-to)137-154
Number of pages18
JournalBlood Reviews
Issue number4
StatePublished - Jul 2012


  • Amyloidosis
  • Monoclonal gammopathy
  • Multisystem disease
  • Prognosis
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology


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