Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus

Phil A. Hart, Pratima Kamada, Kari G. Rabe, Sunil Srinivasan, Ananda Basu, Gaurav Aggarwal, Suresh T. Chari

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Objectives: New-onset diabetes mellitus (DM) may herald pancreatic cancer (PaC). We determined whether changes in body weight distinguished PaC-associated DM (PaCDM) from type 2 DM. Methods: Among Olmsted County residents, we identified 29 PaCDM and 43 type 2 DM subjects who had serial fasting blood glucose measurements, new-onset DM, and no cancer-specific symptoms at DM onset. We compared body weight (kg) and fasting blood glucose (mg/dL) at DM onset, 1 to 2 years before and at index date in the 2 groups. Results: Fasting blood glucose values were similar before and at the onset of DM. Before onset of DM, PaCDM and type 2 DM subjects had similar body weight (P = 0.80). However, at onset of DM, 59% of PaCDM subjects lost weight versus 30% of type 2 DM subjects (P = 0.02). At onset of DM, 56% of type 2 DM subjects gained weight versus 31% of PaCDM subjects (P = 0.04). By index date, PaCDM subjects lost more weight than type 2 DM subjects did (8.3 ± 8.3 vs 0.8 ± 4.8 kg, P < 0.01). Conclusions: Although new-onset primary type 2 DM is typically associated with weight gain, weight loss frequently precedes onset of PaCDM. The paradoxical development of diabetes in the face of ongoing weight loss may be an important clue to understanding the pathogenesis of PaCDM.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
Issue number5
StatePublished - Jul 2011


  • BMI - body mass index
  • DM - diabetes mellitus
  • EUS - endoscopic ultrasound
  • FBG - fasting blood glucose
  • PaC - pancreatic cancer
  • PaCDM - new-onset diabetes mellitus associated with pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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