Walking a fine line between -cell secretion and proliferation

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1 Scopus citations


Of the many common genetic variants associated with type 2 diabetes, that in TCF7L2 remains the most studied because it has the greatest effect size. However, the mechanism by which this variant alters diabetes risk remains elusive. A new study adds another layer of complexity, suggesting that the effects of TCF7L2 are context-dependent, and highlights a novel interaction that might bias a -cell to a secretory or proliferative phenotype. This in turn might open up new avenues to the restoration of insulin secretion in people with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)14190-14191
Number of pages2
JournalJournal of Biological Chemistry
Issue number36
StatePublished - Sep 7 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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