TY - JOUR
T1 - Waldenstrom Macroglobulinemia
T2 - Tailoring Therapy for the Individual
AU - Gertz, Morie A.
N1 - Publisher Copyright:
© American Society of Clinical Oncology.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - With the introduction of multiple new effective therapeutic options for the treatment of macroglobulinemia, a structured approach to management of this rare lymphoma is currently needed. A review of phase II and III treatment trials over the past 20 years was performed, and high-quality trials are summarized in this manuscript. Because of the lack of large prospective trials comparing different classes of therapy, a uniform recommendation applicable to all patients cannot be made, and the approach must be individualized incorporating patient preferences, comorbidities, and the range of therapeutic toxicities. Therapeutic options for patients with newly diagnosed and previously treated macroglobulinemia are presented on the basis of the best available evidence in the literature.
AB - With the introduction of multiple new effective therapeutic options for the treatment of macroglobulinemia, a structured approach to management of this rare lymphoma is currently needed. A review of phase II and III treatment trials over the past 20 years was performed, and high-quality trials are summarized in this manuscript. Because of the lack of large prospective trials comparing different classes of therapy, a uniform recommendation applicable to all patients cannot be made, and the approach must be individualized incorporating patient preferences, comorbidities, and the range of therapeutic toxicities. Therapeutic options for patients with newly diagnosed and previously treated macroglobulinemia are presented on the basis of the best available evidence in the literature.
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U2 - 10.1200/JCO.22.00495
DO - 10.1200/JCO.22.00495
M3 - Review article
C2 - 35700418
AN - SCOPUS:85133845140
SN - 0732-183X
VL - 71
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
M1 - 00495
ER -