TY - JOUR
T1 - Voxel-based morphometry
T2 - An automated technique for assessing structural changes in the brain
AU - Whitwell, Jennifer L.
PY - 2009/8/5
Y1 - 2009/8/5
N2 - In summary, the technique of VBM if implemented correctly is an incredibly powerful and useful tool in the study of neurological disease. It can increase understanding of disease processes, which can be useful both from a scientific point of view and also by providing anatomical information that can be helpful for differential diagnosis of disease. Similar voxel-level statistical techniques can also be applied to other imaging modalities, such as functional MRI and positron emission tomography. It should be stressed, however, that because of the statistical nature of the technique, the power of VBM lies in group analyses. Although it has been applied to single subjects, it has not been optimized or validated for such use. Hence it can provide very important information about regions of atrophy across groups but cannot provide reliable information for single-subject diagnosis. Nevertheless, it is likely to be an important biomarker in future drug trials to assess treatment effects at the group level.
AB - In summary, the technique of VBM if implemented correctly is an incredibly powerful and useful tool in the study of neurological disease. It can increase understanding of disease processes, which can be useful both from a scientific point of view and also by providing anatomical information that can be helpful for differential diagnosis of disease. Similar voxel-level statistical techniques can also be applied to other imaging modalities, such as functional MRI and positron emission tomography. It should be stressed, however, that because of the statistical nature of the technique, the power of VBM lies in group analyses. Although it has been applied to single subjects, it has not been optimized or validated for such use. Hence it can provide very important information about regions of atrophy across groups but cannot provide reliable information for single-subject diagnosis. Nevertheless, it is likely to be an important biomarker in future drug trials to assess treatment effects at the group level.
UR - http://www.scopus.com/inward/record.url?scp=68549125555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68549125555&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2160-09.2009
DO - 10.1523/JNEUROSCI.2160-09.2009
M3 - Review article
C2 - 19657018
AN - SCOPUS:68549125555
SN - 0270-6474
VL - 29
SP - 9661
EP - 9664
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 31
ER -