Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series

Patrick M. Wieruszewski, Scott D. Nei, Simon Maltais, Hartzell V. Schaff, Erica D. Wittwer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalA&A practice
Issue number4
StatePublished - Aug 15 2018

ASJC Scopus subject areas

  • General Medicine


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