Vitamin A toxicity: When one a day doesn't keep the doctor away

Rekha Cheruvattath, Mauricio Orrego, Manjushree Gautam, Thomas Byrne, Shayan Alam, Marina Voltchenok, Mark Edwin, James Wilkens, James W. Williams, Hugo E. Vargas

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Vitamin A toxicity has been reported to cause severe liver disease and, occasionally, liver failure. Herein we present the case of a 60-year-old male with symptoms of muscle soreness, alopecia, nail dystrophy, and ascites. He continued to deteriorate with the development of refractory ascites, renal insufficiency, encephalopathy, and failure to thrive. A liver biopsy demonstrated presence of lto cells and vacuolated Kupffer cells without the presence of cirrhosis. His clinical history revealed ingestion of large doses of vitamin A. His worsening clinical situation ruled out the possibility of a transjugular intrahepatic portosystemic shunt. The patient underwent orthotopic liver transplantation with resolution of symptoms. Vitamin A toxicity should be considered in the differential diagnosis of noncirrhotic portal hypertension. In conclusion, liver transplantation is a valid option if no improvement occurs in spite of cessation of the medication.

Original languageEnglish (US)
Pages (from-to)1888-1891
Number of pages4
JournalLiver Transplantation
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation


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