Virus-Induced Demyelination in Mice: “Dying Back” of Oligodendrocytes


Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Demyelination was produced in mice by intracerebral inoculation of Theiler's murine encephalomyelitis virus. The earliest ultrastructural changes occurred in the inner cytoplasmic tongues of oligodendrocytes, the most distal extension of these cells. Viral antigen was localized to glial loops that connect with myelin lamellae. This study indicates that a “dying-back” process may occur in virus-infected oligodendrocytes, which then results in demyelination.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalMayo Clinic proceedings
Issue number7
StatePublished - 1985

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Virus-Induced Demyelination in Mice: “Dying Back” of Oligodendrocytes'. Together they form a unique fingerprint.

Cite this