Virus-associated hemophagocytic syndrome following bone marrow transplantation

David A. Reardon, Rudolph Roskos, Curtis A. Hanson, Valerie Castle

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Multiple-organ infiltration by mature, benign erythrophagocytic histiocytes is the pathologic hallmark of the virus-associated hemophagocytic syndrome (VAHS). Although VAHS has been described in a number of clinical settings, it has been reported following bone marrow transplantation (BMT) only once previously. Our report identifies the clinical and laboratory features associated with VAHS and compares the immune defects described in VAHS with those known to occur following BMT.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number3
StatePublished - Jan 1 1991


  • Bone marrow transplantation
  • Graft-versus-host disease
  • Immunodeficiency
  • Natural killer cells
  • Virus-associated hemophagocytic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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