Abstract
Individuals with Down syndrome (DS) experience increased risk of Alzheimer’s disease (AD). Recent studies suggest that a vaccine against AD may be forthcoming. Parental buy-in is critical to the success of any intervention in this population, as adults with DS often rely on familial support. This study aims to characterize parents’ perceptions of a hypothetical vaccine to prevent AD in individuals with DS. A mixed-methods, anonymous survey was distributed via social media. Participants were asked about their experiences with DS and reactions to proposed interventions. Open-ended responses were thematically analyzed using NVivo 12. Of 1,093 surveys initiated, 532 were completed. Of the parents sampled (N = 532), a small majority (54.3%), supported the proposed AD vaccine. All expressed the need for extensive pre-enrollment education and minimal risk. For many, limited research and long-term sequelae were concerns.
Original language | English (US) |
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Journal | Journal of Intellectual Disabilities |
DOIs | |
State | Accepted/In press - 2023 |
Keywords
- Alzheimer’s disease
- Trisomy 21
- caregiver
- parent
- vaccine
ASJC Scopus subject areas
- Health Professions (miscellaneous)
- Psychiatry and Mental health