Vibro-acoustography with 1.75D ultrasound array transducer for detection and localization of permanent prostate brachytherapy seeds: Ex vivo study

Mohammad Mehrmohammadi, Azra Alizad, Randall R. Kinnick, Brian J. Davis, Mostafa Fatemi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Effective brachytherapy procedures require precise placement of radioactive seeds in the prostate. Currently, transrectal ultrasound (TRUS) imaging is one of the main intraoperative imaging modalities to assist physicians in placement of brachytherapy seeds. However, the seed detection rate with TRUS is poor mainly because ultrasound imaging is highly sensitive to variations in seed orientation. The purpose of this study is to investigate the abilities of a new acoustic radiation force imaging modality, vibro-acoustography (VA), equipped with a 1.75D array transducer and implemented on a customized clinical ultrasound scanner, to image and localize brachytherapy seeds in prostatic tissue. To perform experiments, excised cadaver prostate specimens were implanted with dummy brachytherapy seeds, and embedded in tissue mimicking gel to simulate the properties of the surrounding soft tissues. The samples were scanned using the VA system and the resulting VA signals were used to reconstruct VA images at several depths inside the tissue. To further evaluate the performance of VA in detecting seeds, X-ray computed tomography (CT) images of the same tissue sample, were obtained and used as a gold-standard to compare the number of seeds detected by the two methods. Our results indicate that VA is capable of imaging of brachytherapy seeds with accuracy and high contrast, and can detect a large percentage of the seeds implanted within the tissue samples.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2013
Subtitle of host publicationUltrasonic Imaging, Tomography, and Therapy
StatePublished - 2013
EventMedical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy - Lake Buena Vista, FL, United States
Duration: Feb 12 2013Feb 14 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Brachytherapy
  • Ex vivo
  • Prostate
  • Seed
  • Ultrasound
  • Vibro-acoustography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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