Vertebral osteomyelitis and prosthetic joint infection due to Staphylococcus simulans

Raymund R. Razonable, David G. Lewallen, Robin Patel, Douglas R. Osmon

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Staphylococcus simulans, a coagulase-negative staphylococcus, is a common animal pathogen that is rarely encountered in human infections. We describe a 70-year-old man who developed multifocal vertebral osteomyelitis and late prosthetic joint infection caused by this pathogen. The patient was a farmer who had daily contact with cows and drank unpasteurized milk, although the portal of the pathogen's entry remains speculative. Culture of the vertebral disk biopsy specimen and cultures during resection arthroplasty yielded S simulans. A review of the literature suggests that S simulans may be more virulent than other species of coagulase-negative staphylococci. Accurate identification of S simulans isolates would facilitate studies to further define its pathogenic role in human infections.

Original languageEnglish (US)
Article number62494
Pages (from-to)1067-1070
Number of pages4
JournalMayo Clinic proceedings
Issue number10
StatePublished - Oct 2001


  • CRP = C-reactive protein
  • CoNS = coagulase-negative staphylococcus
  • ESR = erythrocyte sedimentation rate
  • MRI = magnetic resonance imaging
  • PJI = prosthetic joint infection
  • THA = total hip arthroplasty
  • WBC = white blood cell

ASJC Scopus subject areas

  • Medicine(all)


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