Venous thromboembolism (VTE) prophylaxis for hip and knee arthroplasty: Changing trends

Nicolaas C. Budhiparama, Matthew P. Abdel, Nadia N. Ifran, Sébastien Parratte

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Venous thromboembolism (VTE) has been identified as an immediate threat to patients undergoing major orthopedic procedures such as total hip arthroplasty (THA) and total knee arthroplasty (TKA). Given the known dangers of VTE, arthroplasty surgeons are sensitive to the need for VTE thromboprophylaxis. However, the modalities of thromboprophylaxis used to minimize the risks to patients have been variable. Clinical practice guidelines have been published by several professional organizations, while some hospitals have established their own protocols. The 2 most popular guidelines are those published by the Academy of Orthopaedic Surgeons (AAOS) and American College of Chest Physicians (ACCP), both from North America. Prior to 2012, these recommendations varied depending on underlying definitions, methodology, and goals of the 2 groups. For the first time, both groups have similar recommendations that focus on minimizing symptomatic VTE and bleeding complications. The key to determining the appropriate chemoprophylaxis for patients is to balance efficacy of a prophylactic agent, while being safe in regards to bleeding complications. However, a multimodal approach that focuses on early postoperative mobilization and the use of mechanical prophylaxis, in addition to chemoprophylaxis, is essential.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalCurrent Reviews in Musculoskeletal Medicine
Issue number2
StatePublished - Jun 2014


  • Chemical prophylaxis
  • Clinical guidelines
  • Deep vein thrombosis (DVT)
  • Hip
  • Knee
  • Mechanical prophylaxis
  • Prophylaxis
  • Pulmonary embolism(PE)
  • Thromboprophylaxis
  • Total joint arthroplasty
  • Venous thromboembolism(VTE)

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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