Vector development for cancer gene therapy

With results now coming through from the first trials of gene therapy in tumor patients, it is clear that improvements need to be made to the efficiency of gene delivery vectors. Improvements in vector titre go hand in hand with developments in vector targeting. As well as refining existing vector systems, there is a place now for imaginative thinking to create novel vectors which cross, and extend, established concepts of vector design. These novel vectors will come from combining the beneficial features of different individual systems and looking towards new and untried vectors still waiting to be exploited.