TY - JOUR
T1 - VAPSE-based analysis
T2 - A two-phased candidate gene approach for elucidating genetic predisposition to complex disorders
AU - Weinshenker, Brian G.
AU - Sommer, Steve
N1 - Funding Information:
Dianne Kappas and Theresa Hanron for manuscript preparation. Drs. D. Schaid and J. Heit for critical review of the manuscript. Brian G. Weinshenker is supported by a grant from the National Multiple Sclerosis Society, Grant #RG2870-A-2. Steve S. Sommer is supported by NIH RO1 NS 33354.
PY - 2001
Y1 - 2001
N2 - The extraordinary success of linkage analysis in diseases with Mendelian inheritance has not extended readily to the genetics of common complex diseases. VAPSE-based analysis is a type of candidate gene approach that represents an alternative strategy by which genetic mechanisms can be defined despite the presence of substantial genetic heterogeneity. Recent advances in mutation screening and statistical methodology have enhanced substantially the efficiency and power of this approach. The "bread and butter" of VAPSE-based analysis is genotype-to-phenotype searches in large populations with computerized medical records.
AB - The extraordinary success of linkage analysis in diseases with Mendelian inheritance has not extended readily to the genetics of common complex diseases. VAPSE-based analysis is a type of candidate gene approach that represents an alternative strategy by which genetic mechanisms can be defined despite the presence of substantial genetic heterogeneity. Recent advances in mutation screening and statistical methodology have enhanced substantially the efficiency and power of this approach. The "bread and butter" of VAPSE-based analysis is genotype-to-phenotype searches in large populations with computerized medical records.
KW - Multifactorial disease
KW - SNP/genetic epidemiology
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U2 - 10.1016/S1383-5726(00)00008-X
DO - 10.1016/S1383-5726(00)00008-X
M3 - Article
C2 - 11406417
AN - SCOPUS:0035573902
SN - 1383-5726
VL - 458
SP - 7
EP - 17
JO - Mutation Research - Mutation Research Genomics
JF - Mutation Research - Mutation Research Genomics
IS - 1-2
ER -