Valve replacement for appetite suppressant-induced valvular heart disease

Shankha S. Biswas, Carolyn L. Donovan, Joseph M. Forbess, Stephen H. Royal, Kevin P. Landolfo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Valvular heart disease associated with the use of appetite-suppressant medication is a recently described clinical entity. Although the mechanism of valvular injury remains elusive pathologically, the valvular abnormalities resemble those observed in carcinoid syndrome. The incidence of clinically evident valvular heart disease is low with short-term (less than 3 months) exposure to appetite-suppressant drugs. Prolonged exposure to higher doses in addition to combination drug therapy confers an excess risk for valvular pathologic changes. We report the case of a patient with severe mitral, regurgitation who had short-term exposure (3 weeks) to the combination of fenfluramine (20 mg) and phenteramine (15 mg).

Original languageEnglish (US)
Pages (from-to)1819-1822
Number of pages4
JournalAnnals of Thoracic Surgery
Issue number6
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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