Validation of a Proposed Novel Equation for Estimating LDL Cholesterol

Jeffrey W. Meeusen, Alan J. Lueke, Allan S. Jaffe, Amy K. Saenger

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


BACKGROUND: Aggressive LDL cholesterol (LDL-C) lowering strategies are recommended for primary and secondary prevention of cardiovascular events. A newly derived equation for LDL-C estimation was recently published that addressed limitations in the commonly used Friedewald LDL-C calculation method. The novel method was reported to classify patients with superior concordance to measured LDL-C compared to the Friedewald method, particularly in patients with LDL-C <70 mg/dL METHODS: We evaluated the performance of the novel method within an independent cohort of 23 055 patients with LDL-C measured by the gold standard β-quantification reference method. RESULTS: Overall Friedewald underestimated and the novel method overestimated measured LDL-C. Both estimations significantly deviated from the reference method when LDL-C was <70 mg/dL. Overall, the Friedewald and novel calculations correctly classified 77% and 78% of patients, respectively. The largest discrepancy in classification was observed in individuals with measured LDL-C <70 mg/dL. For this group the novel calculation would reclassify 8.7% of patients as >70 mg/dL compared to the Friedewald equation. CONCLUSIONS: We compared both novel and Friedewald estimated LDL-C against the LDL-C reference method; in contrast, the prior study relied on validation of a subset of samples by β-quantification to allow the use of the vertical autoprofile method for LDL-C measurement. We conclude that the novel method has some benefits but it is unclear whether improvements over the Friedewald calculation are substantive enough to justify making the change in routine clinical practice and to improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)1519-1523
Number of pages5
JournalClinical chemistry
Issue number12
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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