TY - JOUR
T1 - Validation of a pretransplant risk score for new-onset diabetes after kidney transplantation
AU - Chakkera, Harini A.
AU - Chang, Yu Hui
AU - Ayub, Asad
AU - Gonwa, Thomas A.
AU - Weil, E. Jennifer
AU - Knowler, William C.
PY - 2013/10
Y1 - 2013/10
N2 - OBJECTIVE Identification of patients at high risk for new-onset diabetes after kidney transplantation (NODAT) will facilitate clinical trials for its prevention. RESEARCH DESIGN ANDMETHODSdWe previously described a pretransplant predictive risk model for NODAT using seven pretransplant variables (age, planned use of maintenance corticosteroids, prescription for gout medicine, BMI, fasting glucose, fasting triglycerides, and family history of diabetes). We have now applied the initial model to a cohort of 474 transplant recipients from another center for validation.We performed two analyses in the validation cohort. The first was a standardmodel with variables derived fromthe original study. The second was a summary score model, in which the sum of dichotomized variables (all the variables dichotomized at clinically relevant cut points) was used to categorize, individuals into low (0-1), intermediate (2, 3), or high (4-7) risk groups. We also conducted a combined database analyses, merging the initial and validation cohorts (n = 792) to obtain better estimates for a prediction equation. RESULTSdAlthough the frequency of several risk factors differed significantly between the two cohorts, the models performed similarly in each cohort. Using the summary score model, incidences of NODAT in low-risk, medium-risk, and high-risk groups in the initial cohort were 12, 29, and 56%, and in the validation cohort incidences were 11, 29, and 51%. CONCLUSIONSdA pretransplant model for NODAT, including many type 2 diabetes risk factors, predicted NODAT in the validation cohort.
AB - OBJECTIVE Identification of patients at high risk for new-onset diabetes after kidney transplantation (NODAT) will facilitate clinical trials for its prevention. RESEARCH DESIGN ANDMETHODSdWe previously described a pretransplant predictive risk model for NODAT using seven pretransplant variables (age, planned use of maintenance corticosteroids, prescription for gout medicine, BMI, fasting glucose, fasting triglycerides, and family history of diabetes). We have now applied the initial model to a cohort of 474 transplant recipients from another center for validation.We performed two analyses in the validation cohort. The first was a standardmodel with variables derived fromthe original study. The second was a summary score model, in which the sum of dichotomized variables (all the variables dichotomized at clinically relevant cut points) was used to categorize, individuals into low (0-1), intermediate (2, 3), or high (4-7) risk groups. We also conducted a combined database analyses, merging the initial and validation cohorts (n = 792) to obtain better estimates for a prediction equation. RESULTSdAlthough the frequency of several risk factors differed significantly between the two cohorts, the models performed similarly in each cohort. Using the summary score model, incidences of NODAT in low-risk, medium-risk, and high-risk groups in the initial cohort were 12, 29, and 56%, and in the validation cohort incidences were 11, 29, and 51%. CONCLUSIONSdA pretransplant model for NODAT, including many type 2 diabetes risk factors, predicted NODAT in the validation cohort.
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U2 - 10.2337/dc13-0428
DO - 10.2337/dc13-0428
M3 - Article
C2 - 24009296
AN - SCOPUS:84891845427
SN - 0149-5992
VL - 36
SP - 2881
EP - 2886
JO - Diabetes care
JF - Diabetes care
IS - 10
ER -