Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections

Gregory A. Poland, Inna G. Ovsyannikova, Richard B. Kennedy, Iana H. Haralambieva, Robert M. Jacobson

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


In this article we define vaccinomics as the integration of immunogenetics and immunogenomics with systems biology and immune profiling. Vaccinomics is based on the use of cutting edge, high-dimensional (so called "omics") assays and novel bioinformatics approaches to the development of next-generation vaccines and the expansion of our capabilities in individualized medicine. Vaccinomics will allow us to move beyond the empiric "isolate, inactivate, and inject" approach characterizing past vaccine development efforts, and toward a more detailed molecular and systemic understanding of the carefully choreographed series of biological processes involved in developing viral vaccine-induced "immunity." This enhanced understanding will then be applied to overcome the obstacles to the creation of effective vaccines to protect against pathogens, particularly hypervariable viruses, with the greatest current impact on public health. Here we provide an overview of how vaccinomics will inform vaccine science, the development of new vaccines and/or clinically relevant biomarkers or surrogates of protection, vaccine response heterogeneity, and our understanding of immunosenescence.

Original languageEnglish (US)
Pages (from-to)625-636
Number of pages12
JournalOMICS A Journal of Integrative Biology
Issue number9
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics


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