@article{87423d36eb814d19ac81a60fdcb8e85e,
title = "Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus statement",
abstract = "Over the last two decades, the utilization of various novel therapies in the upfront or salvage settings has continued to improve survival outcomes for patients with Multiple Myeloma (MM). Thus, the conventional role for hematopoietic stem cell transplantation (HSCT) in MM either in the form of an autologous stem cell transplant (ASCT) or an allogeneic stem cell transplant (Allo-SCT) warrants re-evaluation, given the aforementioned clinical advances. Here, we present a consensus statement of our multidisciplinary group of over 30 Mayo Clinic physicians with a special interest in the care of patients with MM and provide evidence-based recommendations on the use of HSCT in MM. We specifically address topics that include the role and timing of an ASCT for MM in the era of novel agents, eligibility for an ASCT, post-ASCT consolidation, and maintenance options, and finally the utility of an upfront tandem ASCT, salvage second ASCT, and an allo-SCT in MM.",
author = "Gonsalves, {Wilson I.} and Buadi, {Francis K.} and Sikander Ailawadhi and Bergsagel, {P. Leif} and {Chanan Khan}, {Asher A.} and David Dingli and Angela Dispenzieri and Rafael Fonseca and Hayman, {Susan R.} and Prashant Kapoor and Kourelis, {Taxiarchis V.} and Lacy, {Martha Q.} and Larsen, {Jeremy T.} and Eli Muchtar and Reeder, {Craig B.} and Taimur Sher and Stewart, {A. Keith} and Rahma Warsame and Go, {Ronald S.} and Kyle, {Robert A.} and Nelson Leung and Yi Lin and Lust, {John A.} and Russell, {Stephen J.} and Zeldenrust, {Stephen R.} and Fonder, {Amie L.} and Hwa, {Yi L.} and Hobbs, {Miriam A.} and Mayo, {Angela A.} and Hogan, {William J.} and Rajkumar, {S. Vincent} and Kumar, {Shaji K.} and Gertz, {Morie A.} and Vivek Roy",
note = "Funding Information: Acknowledgements This work is supported in part by grants CA186781 and CA218742 from the National Cancer Institute, National Institutes of Health, as well as the Marion Schwartz Multiple Myeloma Foundation. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2019",
month = mar,
day = "1",
doi = "10.1038/s41409-018-0264-8",
language = "English (US)",
volume = "54",
pages = "353--367",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "3",
}