TY - JOUR
T1 - Utility of Preoperative Laboratory Testing in Assessing Risk of Adverse Outcomes After Anterior Cervical Discectomy and Fusion
T2 - Insights from National Surgical Registry
AU - Zreik, Jad
AU - Goyal, Anshit
AU - Alvi, Mohammed Ali
AU - Freedman, Brett A.
AU - Bydon, Mohamad
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/4
Y1 - 2020/4
N2 - Background: Preoperative laboratory tests are varied in their administration among physicians, and previous studies have published conflicting reports on their utility. Anterior cervical discectomy and fusion (ACDF) is a commonly performed spine surgery, and patients often undergo preoperative testing. We sought to assess the relationship between preoperative laboratory values and risk for adverse postoperative outcomes after ACDF. Methods: The American College of Surgeons–National Surgical Quality Improvement Program was queried from 2012 to 2017 to identify patients undergoing elective ACDF. Multivariable logistic regression was performed to assess the association between abnormal laboratory test values and adverse 30-day outcomes. Relative predictor importance was determined using an importance metric defined as Wald χ2 penalized by degrees of freedom. Results: A total of 47,111 patients were included. On multivariable analysis, high creatinine (P = 0.030), anemia (P < 0.001), hyponatremia (P = 0.034), and leukocytosis (P < 0.001) were found to be significantly associated with any 30-day complications. Anemia (P < 0.001), hypernatremia (P = 0.028), hyponatremia (P = 0.016), and leukocytosis (P < 0.001) were found to be significantly associated with serious 30-day complications. High creatinine (P = 0.027), anemia (P < 0.001), hyponatremia (P = 0.047), and leukocytosis (P = 0.004) were found to be significantly associated with 30-day unplanned readmissions. High blood urea nitrogen (P = 0.007), high creatinine (P = 0.028), anemia (P < 0.001), low platelet count (P < 0.001), hyponatremia (P < 0.001), and leukocytosis (P < 0.001) were found to be significantly associated with nonhome discharge. Predictor importance analysis revealed that abnormal preoperative laboratory values were important determinants in predicting these 30-day outcomes. Conclusions: Our analyses indicate that abnormal preoperative laboratory values are associated with increased risk for adverse outcomes after elective ACDF and can be used in predictive analyses of outcomes.
AB - Background: Preoperative laboratory tests are varied in their administration among physicians, and previous studies have published conflicting reports on their utility. Anterior cervical discectomy and fusion (ACDF) is a commonly performed spine surgery, and patients often undergo preoperative testing. We sought to assess the relationship between preoperative laboratory values and risk for adverse postoperative outcomes after ACDF. Methods: The American College of Surgeons–National Surgical Quality Improvement Program was queried from 2012 to 2017 to identify patients undergoing elective ACDF. Multivariable logistic regression was performed to assess the association between abnormal laboratory test values and adverse 30-day outcomes. Relative predictor importance was determined using an importance metric defined as Wald χ2 penalized by degrees of freedom. Results: A total of 47,111 patients were included. On multivariable analysis, high creatinine (P = 0.030), anemia (P < 0.001), hyponatremia (P = 0.034), and leukocytosis (P < 0.001) were found to be significantly associated with any 30-day complications. Anemia (P < 0.001), hypernatremia (P = 0.028), hyponatremia (P = 0.016), and leukocytosis (P < 0.001) were found to be significantly associated with serious 30-day complications. High creatinine (P = 0.027), anemia (P < 0.001), hyponatremia (P = 0.047), and leukocytosis (P = 0.004) were found to be significantly associated with 30-day unplanned readmissions. High blood urea nitrogen (P = 0.007), high creatinine (P = 0.028), anemia (P < 0.001), low platelet count (P < 0.001), hyponatremia (P < 0.001), and leukocytosis (P < 0.001) were found to be significantly associated with nonhome discharge. Predictor importance analysis revealed that abnormal preoperative laboratory values were important determinants in predicting these 30-day outcomes. Conclusions: Our analyses indicate that abnormal preoperative laboratory values are associated with increased risk for adverse outcomes after elective ACDF and can be used in predictive analyses of outcomes.
KW - ACDF
KW - Cervical
KW - Degenerative spine disease
KW - Laboratory tests
KW - Predictive modeling
KW - Risk stratification
KW - Surgical outcomes
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U2 - 10.1016/j.wneu.2020.01.023
DO - 10.1016/j.wneu.2020.01.023
M3 - Article
C2 - 31931235
AN - SCOPUS:85078864711
SN - 1878-8750
VL - 136
SP - e398-e406
JO - World neurosurgery
JF - World neurosurgery
ER -