TY - JOUR
T1 - Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics
AU - Justilien, Verline
AU - Fields, Alan P.
PY - 2013
Y1 - 2013
N2 - Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.
AB - Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.
KW - Bioluminescent in vivo imaging
KW - Non-small cell lung cancer
KW - Orthotopic model
UR - http://www.scopus.com/inward/record.url?scp=84896350321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896350321&partnerID=8YFLogxK
U2 - 10.1002/0471141755.ph1427s62
DO - 10.1002/0471141755.ph1427s62
M3 - Article
C2 - 24510718
AN - SCOPUS:84896350321
SN - 1934-8282
VL - 1
JO - Current Protocols in Pharmacology
JF - Current Protocols in Pharmacology
IS - SUPPL.62
M1 - 14.27
ER -