TY - JOUR
T1 - Uterine artery embolization versus myomectomy
T2 - A multicenter comparative study
AU - Goodwin, Scott C.
AU - Bradley, Linda D.
AU - Lipman, John C.
AU - Stewart, Elizabeth A.
AU - Nosher, John L.
AU - Sterling, Keith M.
AU - Barth, Merle H.
AU - Siskin, Gary P.
AU - Shlansky-Goldberg, Richard D.
AU - Dong, Paul R.
AU - Broder, Michael S.
AU - Tureck, Richard W.
AU - Bachmann, Gloria A.
AU - Young, Amy E.
AU - Razavi, Mahmood K.
AU - Chen, Bertha H.
AU - Chambers, Theodore P.
AU - Anderson, Glenna R.
AU - Worthington-Kirsch, Robert L.
AU - Thomas, Lynda T.
AU - Reed, Richard A.
AU - Shamsid-Deen, Shafeeq S.
AU - Rothman, Barry S.
AU - Niedzwiecki, Gerald A.
AU - Yeko, Timothy R.
N1 - Funding Information:
S.C.G. has received funding from and is a consultant for Boston Scientific Corporation. This study was funded by grants from Boston Scientific Corporation.
PY - 2006/1
Y1 - 2006/1
N2 - Objective: To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes. Design: Prospective cohort controlled study. Setting: Sixteen medical centers in the United States. Patient(s): One hundred forty-nine UAE patients and 60 myomectomy patients. Patients were assigned to myomectomy or UAE on the basis of a best treatment decision made by the patient and her physician. All patients were observed for 6 months. The UAE patients also had follow-up examinations at 1 year. Intervention(s): Myomectomy or UAE. Main Outcome Measure(s): Quality of life score changes, menstrual bleeding score changes, uterine size differences, time off, and adverse events. Result(s): Both groups experienced statistically significant improvements in the uterine fibroid quality of life score, menstrual bleeding, uterine volume, and overall postoperative quality of life. The mean hospital stay was 1 day for the UAE patients, compared with 2.5 days for the myomectomy patients. The UAE and myomectomy patients returned to their normal activities in 15 days and 44 days, respectively, and returned to work in 10 days and 37 days, respectively. At least one adverse event occurred in 40.1% of the myomectomy patients, compared with 22.1% in the UAE group. Conclusion(s): The uterine fibroid quality of life score was significantly improved in both groups. No significant differences were observed in bleeding improvement, uterine volume reduction, uterine fibroid quality of life score improvement, and overall quality of life score improvement between groups. Patients receiving UAE required fewer days off work, fewer hospital days, and experienced fewer adverse events.
AB - Objective: To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes. Design: Prospective cohort controlled study. Setting: Sixteen medical centers in the United States. Patient(s): One hundred forty-nine UAE patients and 60 myomectomy patients. Patients were assigned to myomectomy or UAE on the basis of a best treatment decision made by the patient and her physician. All patients were observed for 6 months. The UAE patients also had follow-up examinations at 1 year. Intervention(s): Myomectomy or UAE. Main Outcome Measure(s): Quality of life score changes, menstrual bleeding score changes, uterine size differences, time off, and adverse events. Result(s): Both groups experienced statistically significant improvements in the uterine fibroid quality of life score, menstrual bleeding, uterine volume, and overall postoperative quality of life. The mean hospital stay was 1 day for the UAE patients, compared with 2.5 days for the myomectomy patients. The UAE and myomectomy patients returned to their normal activities in 15 days and 44 days, respectively, and returned to work in 10 days and 37 days, respectively. At least one adverse event occurred in 40.1% of the myomectomy patients, compared with 22.1% in the UAE group. Conclusion(s): The uterine fibroid quality of life score was significantly improved in both groups. No significant differences were observed in bleeding improvement, uterine volume reduction, uterine fibroid quality of life score improvement, and overall quality of life score improvement between groups. Patients receiving UAE required fewer days off work, fewer hospital days, and experienced fewer adverse events.
KW - Embolization
KW - Fibroid
KW - Liomyoma
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U2 - 10.1016/j.fertnstert.2005.05.074
DO - 10.1016/j.fertnstert.2005.05.074
M3 - Article
C2 - 16412720
AN - SCOPUS:30344459722
SN - 0015-0282
VL - 85
SP - 14
EP - 21
JO - Fertility and sterility
JF - Fertility and sterility
IS - 1
ER -