TY - JOUR
T1 - Using Speed of Sound Imaging to Characterize Breast Density
AU - Sak, Mark
AU - Duric, Neb
AU - Littrup, Peter
AU - Bey-Knight, Lisa
AU - Ali, Haythem
AU - Vallieres, Patricia
AU - Sherman, Mark E.
AU - Gierach, Gretchen L.
N1 - Funding Information:
The authors wish to thank Dr. Norman Boyd for his work analyzing all mammograms and Ms. Vivian Linke for research assistance. The authors are indebted to the participants in the Ultrasound Study of Tamoxifen for their outstanding cooperation and to the physicians, pathologists, nurses and technologists for their efforts in the field. This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute. The authors acknowledge the support of the National Institutes of Health through contract No HHSN261201400038P and grant No R44 CA165320 from the National Cancer Institute .
Publisher Copyright:
© 2016 World Federation for Ultrasound in Medicine & Biology
PY - 2017/1/1
Y1 - 2017/1/1
N2 - A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0.722, p < 0.001) and UST median sound speed (rs = 0.737, p < 0.001). Both were stronger than the associations between MPD with two separate measures of UST percent density, a k-means (rs = 0.568, p < 0.001) or a threshold (rs = 0.715, p < 0.001) measure. Segmentation of the UST sound speed images into dense and non-dense volumes showed weak to moderate associations with the mammographically equivalent measures. Relationships were found to be inversely and weakly associated between age and the UST mean sound speed (rs = −0.239, p = 0.002), UST median sound speed (rs = −0.226, p = 0.004) and MPD (rs = −0.204, p = 0.008). Relationships were found to be inversely and moderately associated between body mass index (BMI) and the UST mean sound speed (rs = −0.429, p < 0.001), UST median sound speed (rs = −0.447, p < 0.001) and MPD (rs = −0.489, p < 0.001). The results confirm and strengthen findings presented in previous work indicating that UST sound speed imaging yields viable markers of breast density in a manner consistent with mammography, the current clinical standard. These results lay the groundwork for further studies to assess the role of sound speed imaging in risk prediction.
AB - A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0.722, p < 0.001) and UST median sound speed (rs = 0.737, p < 0.001). Both were stronger than the associations between MPD with two separate measures of UST percent density, a k-means (rs = 0.568, p < 0.001) or a threshold (rs = 0.715, p < 0.001) measure. Segmentation of the UST sound speed images into dense and non-dense volumes showed weak to moderate associations with the mammographically equivalent measures. Relationships were found to be inversely and weakly associated between age and the UST mean sound speed (rs = −0.239, p = 0.002), UST median sound speed (rs = −0.226, p = 0.004) and MPD (rs = −0.204, p = 0.008). Relationships were found to be inversely and moderately associated between body mass index (BMI) and the UST mean sound speed (rs = −0.429, p < 0.001), UST median sound speed (rs = −0.447, p < 0.001) and MPD (rs = −0.489, p < 0.001). The results confirm and strengthen findings presented in previous work indicating that UST sound speed imaging yields viable markers of breast density in a manner consistent with mammography, the current clinical standard. These results lay the groundwork for further studies to assess the role of sound speed imaging in risk prediction.
KW - Breast Cancer
KW - Breast density
KW - Dense and non-dense breast volumes
KW - Mammography
KW - Risk assessment
KW - Sound speed
KW - Ultrasound tomography
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U2 - 10.1016/j.ultrasmedbio.2016.08.021
DO - 10.1016/j.ultrasmedbio.2016.08.021
M3 - Article
C2 - 27692872
AN - SCOPUS:84999636172
SN - 0301-5629
VL - 43
SP - 91
EP - 103
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 1
ER -