Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

Victoria Wahl-Jensen; Laura Bollinger; David Safronetz; Fabian De Kok-Mercado; Dana P. Scott; Hideki Ebihara

doi:10.3390/v4123754

Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

Victoria Wahl-Jensen, Laura Bollinger, David Safronetz, Fabian De Kok-Mercado, Dana P. Scott, Hideki Ebihara

Molecular Medicine

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.

Original language	English (US)
Pages (from-to)	3754-3784
Number of pages	31
Journal	Viruses
Volume	4
Issue number	12
DOIs	https://doi.org/10.3390/v4123754
State	Published - 2012

Keywords

Ebola
Filovirus
Hamster model
Pathogenesis
Rodent model

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v4123754

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title = "Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers",

abstract = "Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.",

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AU - Wahl-Jensen, Victoria

AU - Bollinger, Laura

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AU - De Kok-Mercado, Fabian

AU - Scott, Dana P.

AU - Ebihara, Hideki

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AB - Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.

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KW - Filovirus

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KW - Pathogenesis

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Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

Abstract

Keywords

ASJC Scopus subject areas

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