Use of noninvasive gas exchange to track pulmonary vascular responses to exercise in heart failure

Bryan J. Taylor, Thomas P. Olson, Chul Ho Kim, Dean MacCarter, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We determined whether a non-invasive gas exchange based estimate of pulmonary vascular (PV) capacitance [PVCAP = stroke volume (SV) × pulmonary arterial pressure (Ppa)] (GXCAP) tracked the PV response to exercise in heart-failure (HF) patients. Pulmonary wedge pressure (Ppw), Ppa, PV resistance (PVR), and gas exchange were measured simultaneously during cycle exercise in 42 HF patients undergoing right-heart catheterization. During exercise, PETCO2 and VE/VCO2 were related to each other (r = -0.93, P < 0.01) and similarly related to mean Ppa (mPpa) (r = -0.39 and 0.36; P < 0.05); PETCO2 was subsequently used as a metric of mPpa. Oxygen pulse (O2 pulse) tracked the SV response to exercise (r = 0.91, P < 0.01). Thus, GXCAP was calculated as O2 pulse × PETCO2. During exercise, invasively determined PVCAP and non-invasive GXCAP were related (r = 0.86, P < 0.01), and GXCAP correlated with mPpa and PVR (r = -0.46 and -0.54; P < 0.01). In conclusion, noninvasive gas exchange measures may represent a simple way to track the PV response to exercise in HF.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalClinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
Issue number1
StatePublished - 2013


  • Capacitance
  • Exercise
  • Gas exchange
  • Pulmonary vasculature
  • Vasculature

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Use of noninvasive gas exchange to track pulmonary vascular responses to exercise in heart failure'. Together they form a unique fingerprint.

Cite this