Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction

Adrianus A.J. Smit, Wouter Wieling, Jiro Fujimura, Jong C. Denq, Tonette L. Opfer-Gehrking, Mohammed Akarriou, John M. Karemaker, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


The aim of this study was to investigate in patients with neurogenic orthostatic hypotension the mechanism and usefulness of abdominal compression to increase standing blood pressure. In three protocols, 23 patients underwent abdominal compression. Protocol 1 evaluated in a 40-60° head-up-tilt position, the effect of abdominal compression on caval vein and femoral diameter, arterial blood pressure and hemodynamics. Protocol 2 documented the relationship between the level of compression and the arterial pressure response. Protocol 3 investigated the ability to maintain standing blood pressure by an elastic binder. During head-up-tilt, compression (40 mm Hg) resulted in a reduction in diameter of the caval vein (mean -2.6 mm, range -1.4 to 0.6), without a change in femoral vein diameter. Stroke volume increased by 14% (range -1 to 23) and blood pressure (systolic/diastolic) by 30/14 mm Hg (range 7/2 to 69/36), both p < 0.05; 40 mm Hg compression was associated with a higher pressure response than 20 mm Hg (mean 18/8 mm Hg, range 6/2 to 43/20 vs. mean 9/4 mm Hg, range -1/0 to 18/8, p < 0.05). Elastic abdominal binding increased standing blood pressure with 15/6 mm Hg (range -3/3 to 36/14, p < 0.05). We conclude that in patients with neurogenic orthostatic hypotension, abdominal compression increases standing blood pressure to a varying degree by increasing stroke volume.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalClinical Autonomic Research
Issue number3
StatePublished - Jun 2004


  • Abdominal compression
  • Autonomic dysfunction
  • Autonomic nervous system
  • Blood pressure
  • Braces

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology


Dive into the research topics of 'Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction'. Together they form a unique fingerprint.

Cite this