Abstract
The prevalence of Alzheimer's disease is greater in women, but the underlying mechanisms remain to be elucidated. We herein demonstrated that α-secretase ADAM10 was downregulated and ADAM10 inhibitor sFRP1 was upregulated in 5xFAD mice. While there were no sex effects on ADAM10 protein and sFRP1 mRNA levels, female 5xFAD and age-matched non-transgenic mice exhibited higher levels of sFRP1 protein than corresponding male mice. Importantly, female 5xFAD mice accumulated more Aβ than males, and sFRP1 protein levels were positively associated with Aβ42 levels in 5xFAD mice. Our study suggests that sFRP1 is associated with amyloid pathology in a sex-dependent manner.
Original language | English (US) |
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Pages (from-to) | 399-405 |
Number of pages | 7 |
Journal | Journal of Alzheimer's Disease |
Volume | 95 |
Issue number | 2 |
DOIs | |
State | Published - 2023 |
Keywords
- 5xFAD mice
- Alzheimer's disease
- AβPP
- amyloid-β
- sFRP1
- sex-dependent effects
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health