Update on intravenous leiomyomatosis: Report of five patients and literature review

Victoria Valdés Devesa, Christopher R. Conley, William M. Stone, Joseph M. Collins, Javier F. Magrina

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The objective of this study was to review management and results of surgical therapy of intravenous leiomyomatosis (IVL). A retrospective review of five patients treated at the Mayo Clinic between 2002 and 2012 and a literature review from 1970 to the present were performed. IVL is a rare condition, often overlooked, misdiagnosed or inadequately treated. Despite its benign histological features, invasion of large vessels and cardiac extension can occur and be fatal. Appropriate diagnosis and a radical surgical approach to IVL provide optimal outcomes. Incomplete resection and/or microscopic foci of IVL can lead to recurrence. Surgery should always aim for complete tumor excision and include hysterectomy and bilateral salpingoophorectomy. Radical parametrectomy and intravenous tumor resection may be necessary.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
StatePublished - Dec 2013


  • Hysterectomy
  • Intravenous leiomyomatosis
  • Leiomyomatosis
  • Smooth muscle tumors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


Dive into the research topics of 'Update on intravenous leiomyomatosis: Report of five patients and literature review'. Together they form a unique fingerprint.

Cite this