Uniform data set language measures for bvftd and ppa diagnosis and monitoring

Adam M. Staffaroni, Sandra Weintraub, Katya Rascovsky, Katherine P. Rankin, Jack Taylor, Julie A. Fields, Kaitlin B. Casaletto, Argye E. Hillis, Sladjana Lukic, Maria Luisa Gorno-Tempini, Hilary Heuer, Merilee A. Teylan, Walter A. Kukull, Bruce L. Miller, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer, Joel H. Kramer

Research output: Contribution to journalArticlepeer-review


Introduction: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring. Methods: Linear regressions compared baseline performances in 1655 National Alzheimer’s Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n = 612), semantic variant primary progressive aphasia (svPPA, n = 185), non-fluent/agrammatic variant PPA (nfvPPA, n = 168), logopenic variant PPA (lvPPA, n = 109), and controls (n = 581)). Sample sizes to detect treatment effects were estimated using longitudinal data. Results: Among PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change. Discussion: The FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.

Original languageEnglish (US)
Article numbere12148
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number1
StatePublished - 2021


  • Clinical trials
  • Cognition
  • Differential diagnosis
  • Endpoints
  • FTLD module
  • Frontotemporal dementia (FTD)
  • Longitudinal
  • Neuropsychology
  • Primary progressive aphasia (PPA)
  • Speech

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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